{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:27:56Z","timestamp":1768728476563,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>FA ethyl esters (FAEE) are nonoxidative metabolites of ethanol produced by the esterification of FA and ethanol. FAFF have been implicated as mediators of ethanol\u2010induced organ damage <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>, and are markers of ethanol intake. Upon ethanol intake, FAEE are synthesized in the liver and pancreas in significant quantities. There is limited information on the stimulation of FAEE synthesis upon addition of exogenous FA <jats:italic>in vitro<\/jats:italic>. HepG2 cells were incubated with ethanol alone, ethanol with 25 \u03bcM linoleate, and ethanol with 25 \u03bcM stearate. The amount of FAFF in human hepatoblastoma (HepG2) cells was determined 1\u20133 h after ethanol and FA addition. Stearate increased the FAEE concentration in HepG2 cells when incubated with the cells for 1 h, whereas linoleate did not increase the cellular FAEE concentration at any time. Ethyl palmitate, ethyl stearate, and ethyl oleate were the predominant FAEE species identified in all cases, independent of the specific supplemental FA added to the medium.<\/jats:p>","DOI":"10.1007\/s11745-006-1160-3","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T23:12:11Z","timestamp":1224544331000},"page":"1051-1055","source":"Crossref","is-referenced-by-count":3,"title":["Stearic acid stimulates FA ethyl ester synthesis in HepG2 cells exposed to ethanol"],"prefix":"10.1002","volume":"38","author":[{"given":"Ali","family":"Hasaba","sequence":"first","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology Massachusetts General Hospital and Harvard Medical School 55 Fruit St.\u2010Gray 235 Boston Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne E.","family":"Cluette\u2010Brown","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology Massachusetts General Hospital and Harvard Medical School 55 Fruit St.\u2010Gray 235 Boston Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Laposata","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology Massachusetts General Hospital and Harvard Medical School 55 Fruit St.\u2010Gray 235 Boston Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"891","volume-title":"Hepatology: A Textbook of Liver Diseases","author":"Nanji A.A.","year":"1996"},{"key":"e_1_2_2_3_1","first-page":"85","article-title":"Metabolism and Metabolic Effects of Alcohol","volume":"17","author":"Lieber C.S.","year":"1980","journal-title":"Semin. 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