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New Zealand White male rabbits (9.6 weeks; 2.1 kg) were assigned for 6 or 12 weeks to three diets (<jats:italic>n<\/jats:italic> = 6 per diet) made of conventional pellets with 0.2% cholesterol and with 12% fat provided from a butter poor in <jats:italic>trans<\/jats:italic>\u201010 and <jats:italic>trans<\/jats:italic>\u201011 18:1 and in CLA (standard group), or rich in <jats:italic>trans\u2010<\/jats:italic>10 18:1 (<jats:italic>trans<\/jats:italic>\u201010 18:1 group) or rich in <jats:italic>trans<\/jats:italic>\u201011 18:1 and in <jats:italic>cis<\/jats:italic>\u20109,<jats:italic>trans<\/jats:italic>\u201011 CLA (<jats:italic>trans<\/jats:italic>\u201011 18:1\/CLA group). Blood samples were collected at the end of dietary treatments. Lipoproteins were separated by gradient\u2010density ultracentrifugation. Lipid classes were determined enzymatically and apolipoproteins A\u2010I and B by radial immunodiffusion. Mainly in the 12\u2010week rabbits, higher plasma triglycerides and apolipoprotein B levels shown in the standard and <jats:italic>trans<\/jats:italic>\u201010 18:1 groups compared with those in the <jats:italic>trans<\/jats:italic>\u201011 18:1\/CLA group are associated with higher plasma levels of very low density lipoproteins (VLDL) and low density lipoproteins (LDL) also shown in these two groups. In the 12\u2010week rabbits, a shift towards denser LDL, considered as more atherogenic, was shown only in the <jats:italic>trans<\/jats:italic>\u201010 18:1 group. In these animals, the VLDL + LDL to HDL ratio was 1.7\u20132.3 times higher in the <jats:italic>trans<\/jats:italic>\u201010 18:1 group than in the other groups (<jats:italic>P<\/jats:italic> = 0.076). These results suggest a rather neutral effect of <jats:italic>trans<\/jats:italic>\u201011 18:1\/CLA butter towards the risk of atherogenesis, whereas <jats:italic>trans<\/jats:italic>\u201010 18:1 butter would tend to be detrimental.<\/jats:p>","DOI":"10.1007\/s11745-006-3018-0","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T11:17:05Z","timestamp":1169810225000},"page":"123-133","source":"Crossref","is-referenced-by-count":85,"title":["Butters Varying in <i>trans<\/i> 18:1 and <i>cis<\/i>\u20109,<i>trans\u2010<\/i>11 Conjugated Linoleic Acid Modify Plasma Lipoproteins in the Hypercholesterolemic Rabbit"],"prefix":"10.1002","volume":"42","author":[{"given":"Dominique","family":"Bauchart","sequence":"first","affiliation":[{"name":"UR1213 Herbivores, Research Unit on Herbivores, Nutrients and Metabolisms Group INRA Site de Theix Saint\u2010Gen\u00e8s\u2010Champanelle 63122 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