{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:26:47Z","timestamp":1791019607624,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to characterize plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either <jats:italic>cis\u20109, trans<\/jats:italic>\u201011 CLA (9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA); <jats:italic>trans<\/jats:italic>\u201010, <jats:italic>cis<\/jats:italic>\u201012 CLA (10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in hypercholesterolemic hamsters. One hundred male F<jats:sub>1<\/jats:sub>B strain Syrian Golden Hamsters (<jats:italic>Mesocricetus auratus)<\/jats:italic> (BioBreeders Inc., Watertown, MA) approximately 9 wk of age were housed in individual stainless stel hanging cages at room temperature with a 12\u2010h light\/dark cycle. Hamsters were given food and water <jats:italic>ad libitum<\/jats:italic>. Following a 1\u2010wk period of acclimation, the hamsters were fed a chow\u2010based (nonpurified) hypercholesterolemic diet (HCD) contaning 10% coconut oil (92% saturated fat) and 0.1% cholesterol for 2 wk. After an overnight fast, the hamsters were bled and plasma cholesterol concentrations were measured. The hamsters were then divided into 4 groups of 25 based on similar mean plasma VLDL and LDL cholesterol (non HDL\u2010C) concentrations. Group <jats:bold>1<\/jats:bold> remained on the HCD (control). Group 2 was fed the HCD plus 0.5% 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer. Group 3 was fed the HCD plus 0.5% 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer. Group 4 was fed the HCD plus 0.5% LA. Compared with the control, both CLA isomers and LA had significantly lower plasma total cholesterol and HDL cholesterol concentrations (<jats:italic>P<\/jats:italic>&lt;0.001) after 12 but not 8 wk of treatment and were not significantly different from each other. Also, both CLA isomers had significantly lower plasma non HDL\u2010C concentrations (<jats:italic>P<\/jats:italic>&lt;0.01) compared with the control after 12 but not 8 wk of treatment and were not significantly different from each other or the LA\u2010fed hamsters. Plasma TG concentrations were significantly higher (<jats:italic>P<\/jats:italic>&lt;0.004) with the 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer compared with the other treatments at 8 but not at 12 wk of treatment. Plasma TG concentrations were also significantly lower (<jats:italic>P<\/jats:italic>&lt;0.03) with the 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer compared with the control at 12 wk of treatment. Also, the 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer and LA had significantly higher plasma glucose concentrations compared with the control and 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer (<jats:italic>P<\/jats:italic>&lt;0.008) at 12 wk of treatment whereas at 8 wk, only the LA treatment had significantly higher plasma glucose concentrations (<jats:italic>P<\/jats:italic>&lt;0.001) compared with the 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer. Although liver weights were significantly higher in 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer\u2010fed hamsters, liver total cholesterol, free cholesterol, cholesterol ester, and TG concentrations were significantly lower in these hamsters compared with hamsters fed the control, 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer, and LA diets (<jats:italic>P<\/jats:italic>&lt;0.05). The 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer and LA diets tended to reduce cholesterol accumulation in the aortic arch, whereas the 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer diet tended to raise cholesterol accumulation compared with the control diet; however, neither was significant. In summary, no differences were observed between the CLA isomers for changes in plasma lipids or lipoprotein cholesterol concentrations. However, the 9<jats:italic>c<\/jats:italic>, 11<jats:italic>t<\/jats:italic> CLA isomer did appear to lower plasma TG and glucose concentrations compared with the 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer. Such differences may increase the risk of insulin resistance and type 2 diabetes in humans when the 10<jats:italic>t<\/jats:italic>, 12<jats:italic>c<\/jats:italic> CLA isomer is fed separately.<\/jats:p>","DOI":"10.1007\/s11745-006-5068-8","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T05:21:25Z","timestamp":1171689685000},"page":"41-48","source":"Crossref","is-referenced-by-count":39,"title":["Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters"],"prefix":"10.1002","volume":"41","author":[{"given":"Thomas A.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory and Nutritional Sciences. Center for Health and Disease Research University of Massachusetts Lowell 3 Solomont Way, Suite 4 Lowell MA 01854\u20105125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Nicolosi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory and Nutritional Sciences. Center for Health and Disease Research University of Massachusetts Lowell 3 Solomont Way, Suite 4 Lowell MA 01854\u20105125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Saati","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory and Nutritional Sciences. Center for Health and Disease Research University of Massachusetts Lowell 3 Solomont Way, Suite 4 Lowell MA 01854\u20105125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Kotyla","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory and Nutritional Sciences. 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