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Our objective was to examine the effects of sitostanol as sitostanol ester in softgel form on serum lipid concentrations in hypercholesterolemic individuals. Thirty hypercholesterolemic adults were supplemented with 1.6 g of free phytostanol equivalents as phytostanol ester (2.7 g stanol esters) or placebo per day for 28 d in a randomized, double\u2010blind, parallel study design. Phytostanol supplementation resulted in a significant decrease in total cholesterol (TC) (\u22128%) and LDL\u2010cholesterol (\u22129%). There were no alterations in concentrations of HDL\u2010cholesterol or TG. Nor were the ratios of LDL\/HDL or TC\/HDL altered significantly. Thus, use of phytostanol ester softgel supplements improved serum total and LDL\u2010cholesterol concentrations in hypercholesterolemic individuals.<\/jats:p>","DOI":"10.1007\/s11745-006-5080-z","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T05:45:17Z","timestamp":1171691117000},"page":"127-132","source":"Crossref","is-referenced-by-count":26,"title":["Cholesterol\u2010lowering ability of a phytostanol softgel supplement in adults with mild to moderate hypercholesterolemia"],"prefix":"10.1002","volume":"41","author":[{"given":"Derek","family":"Woodgate","sequence":"first","affiliation":[{"name":"Department of Human Biology and Nutritional Sciences University of Guelph Guelph Ontario N1G 5B6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina H. 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