{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:33:22Z","timestamp":1791178402395,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lysobisphosphatidic acid (LBPA) is highly accumulated in specific domains of the late endosome and is involve in the biogenesis and function of this organelle. Little is known about the biosynthesis and metabolism of this lipid. We examined its FA composition and the incorporation of exogenous FA into LBPA in the human monocytic leukemia cell line THP\u20101. The LBPA FA composition in THP\u20101 cells exhibits an elevated amount of oleic acid (18\u22361n\u22129) and enerichment of PUFA, especially DHA (22\u22366n\u22123). DHA supplemented to the medium was efficiently incorporated into LBPA. In contrast, arachidonic acid (20\u22364n\u22126) was hardly esterified to LBPA under the same experimental conditions. The turnover of DHA in LBPA was similar to that in other phospholipids. Specific incorporation of DHA into LBPA was also observed in baby hamster kidney fibroblasts, although LBPA in these cells contains very low endogenous levels of DHA in normal growth conditions. Our results, together with published observations, suggest that the specific incorporation of DHA into LBPA is a common phenomenon in mammalian cells. The physiological significance of DHA\u2010enriched LBPA is discussed.<\/jats:p>","DOI":"10.1007\/s11745-006-5087-5","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T05:45:17Z","timestamp":1171691117000},"page":"189-196","source":"Crossref","is-referenced-by-count":24,"title":["Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP\u20101 macrophages"],"prefix":"10.1002","volume":"41","author":[{"given":"Nelly","family":"Besson","sequence":"first","affiliation":[{"name":"Institut National des Sciences Appliqu\u00e9es (INSA)\u2010Lyon, Institut Multidisciplinaire de Biochimie des Lipides Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 585 Villeurbanne 69621 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Hullin\u2010Matsuda","sequence":"additional","affiliation":[{"name":"Institut National des Sciences Appliqu\u00e9es (INSA)\u2010Lyon, Institut Multidisciplinaire de Biochimie des Lipides Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 585 Villeurbanne 69621 France"},{"name":"RIKEN 20 Ave A. Einstein Saitama 351\u20100198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Makino","sequence":"additional","affiliation":[{"name":"RIKEN 20 Ave A. Einstein Saitama 351\u20100198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohide","family":"Murate","sequence":"additional","affiliation":[{"name":"RIKEN 20 Ave A. Einstein Saitama 351\u20100198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lagarde","sequence":"additional","affiliation":[{"name":"Institut National des Sciences Appliqu\u00e9es (INSA)\u2010Lyon, Institut Multidisciplinaire de Biochimie des Lipides Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 585 Villeurbanne 69621 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Francois","family":"Pageaux","sequence":"additional","affiliation":[{"name":"Institut National des Sciences Appliqu\u00e9es (INSA)\u2010Lyon, Institut Multidisciplinaire de Biochimie des Lipides Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 585 Villeurbanne 69621 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Institut National des Sciences Appliqu\u00e9es (INSA)\u2010Lyon, Institut Multidisciplinaire de Biochimie des Lipides Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 585 Villeurbanne 69621 France"},{"name":"RIKEN 20 Ave A. Einstein Saitama 351\u20100198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Delton\u2010Vandenbroucke","sequence":"additional","affiliation":[{"name":"Institut National des Sciences Appliqu\u00e9es (INSA)\u2010Lyon, Institut Multidisciplinaire de Biochimie des Lipides Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 585 Villeurbanne 69621 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.9.1512"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216452"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35096054"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2001.059"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202838200"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/32440"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.2.563"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/10084"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2004.08.009"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2004.08.014"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(74)90034-6"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00016a029"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41687-6"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39998-3"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107052"},{"key":"e_1_2_2_18_1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.4049\/jimmunol.138.6.1877","article-title":"Regulation of Arachidonic Acid Metabolism in Resident and BCG\u2010Activated Alveolar Macrophages: Role of Lyso(bis)phosphatidic Acid","volume":"138","author":"Cochran F.R.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3510795"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00392-0"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.213S"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80072-5"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02537039"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:2005046"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(03)00101-4"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02041244"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.10.1589"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-0624-8"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.4.1301"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0102"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32169-6"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.32.20121"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.5.1829"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)80026-6"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.13503"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.5.681"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(93)90252-5"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(86)90290-0"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.1.4.3653583"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(92)90063-2"},{"key":"e_1_2_2_42_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0065-3101(24)00102-6","article-title":"Niemann\u2013Pick Disease: Newer Classification Based on Genetic Mutations of the Disease","volume":"41","author":"Weisz B.","year":"1994","journal-title":"Adv. Pediatr."},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a129695"},{"key":"e_1_2_2_44_1","first-page":"613","article-title":"Drug\u2010Induced Lipidosis in Human Cases and in Animal Experiments. Accumulation of an Acidic Glycerophospholipid","volume":"69","author":"Yamamoto A.","year":"1971","journal-title":"J. Biochem. (Tokyo)"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89718-6"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(99)00021-9"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.4.1064S"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00861-6"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132106"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0695-7"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-006-5087-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:47:04Z","timestamp":1760968024000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-006-5087-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1007\/s11745-006-5087-5"],"URL":"https:\/\/doi.org\/10.1007\/s11745-006-5087-5","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}