{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:38:09Z","timestamp":1773419889125,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dietary CLA has been shown to enhance glucose tolerance in several animal models, but in mice it induces insulin resistance and lipodystrophy. In this study, the effects of 2 wk of diet supplementation with either 1,5% CLA or 0.2% troglitazone (TZD), an insulin\u2010sensitizing thiazolidinedione, on glucose tolerance, lipid accumulation, and composition of both lean and Zucker diabetic fatty (<jats:italic>fa\/fa<\/jats:italic>; ZDF) rats were examined. Compared with lean rats, which maintained normal glucose tolerances after 2 wk of feeding regardless of diet, ZDF rats fed a control diet (CON) had significantly worsened glucose tolerance. ZDF rats fed CLA and TZD diets, however, maintained normal glucose tolerances. In contrast to the significantly elevated lipid levels in ZDF rats fed the CON diet, concentrations of plasma FFA and TG in ZDF rats fed CLA and TZD diets were normalized. A similar reduction of plasma lipid levels was observed in lean rats fed CLA and TZD compared with lean rats fed the CON diet. Although ZDF CON rats developed significant hepatic steatosis, both CLA\u2010and TZD\u2010fed rats had hepatic TG levels similar to those of lean rats. Both lean and ZDF rats fed the CLA diet had reduced adipose mass compared with respective genotype controls; however, TZD had no effect. Ratios of 16\u22361\/16\u22360 and 18\u22361\/18\u22360 FA, surrogate markers for stearoyl\u2010CoA desaturase\u20101 (SCD\u20101) activity, were reduced in livers of ZDF rats fed CLA and TZD diets. These results show that, like TZD, CLA normalizes glucose tolerance and plasma lipids and also improves hepatic steatosis and FA composition in ZDF rats. The effects of CLA and TZD on hepatic lipid composition suggest that the effects of these two agents on glucose tolerance may be associated with a reduction in SCD\u20101.<\/jats:p>","DOI":"10.1007\/s11745-006-5093-7","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T05:37:24Z","timestamp":1171690644000},"page":"241-247","source":"Crossref","is-referenced-by-count":19,"title":["Effects of conjugated linoleic acid and troglitazone on lipid accumulation and composition in lean and Zucker diabetic fatty (<i>fa\/fa<\/i>) rats"],"prefix":"10.1002","volume":"41","author":[{"given":"Angela A.","family":"Wendel","sequence":"first","affiliation":[{"name":"Dept. of Human Nutrition The Ohio State University 1787 Neil Ave. Columbus OH 43210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha A.","family":"Belury","sequence":"additional","affiliation":[{"name":"Dept. of Human Nutrition The Ohio State University 1787 Neil Ave. Columbus OH 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