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To further understand how specific brain processes and systems are affected by variation in brain DHA content, we sought to determine whether specific brain regions were differentially affected by treatments that after brain DHA content. Adult male Long\u2010Evans rats were raised from conception using diet\/breeding treatments to produce four groups with distinct brain phospholipid compositions. Total phospholipid FA composition was determined in whole brain and 15 brain regions by TLC\/GC. Brain regions exhibited significantly different DHA contents, with the highest levels observed in the frontal cortex and the lowest in the substantia nigra\/ventral tegmental area. Increased availability of DHA resulted in increased DHA content only in the olfactory bulb, parietal cortex, and substantia nigra\/ventral tegmental area. In contrast, treatment that decreased whole\u2010brain DHA levels decreased DHA content in all brain regions except the thalamus, dorsal midbrain, and the substantia nigra\/ventral tegmental area. Alterations in DHA level were accompanied by changes in docosapentaenoic acid (n\u22126 DPA, 22\u22365n\u22126) content; however, the change in DHA and n\u22126 DPA was nonreciprocal in some brain regions. These findings demonstrate that the FA compositions of specific brain regions are differentially affected by variation in DHA availability during development. These differential effects may contribute to the specific neurochemical and behavioral effects observed in animals with variation in brain DHA content.<\/jats:p>","DOI":"10.1007\/s11745-006-5114-6","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T05:41:36Z","timestamp":1171690896000},"page":"407-414","source":"Crossref","is-referenced-by-count":28,"title":["Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain"],"prefix":"10.1002","volume":"41","author":[{"given":"Beth","family":"Levant","sequence":"first","affiliation":[{"name":"Department of Toxicology University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of Therapeutics University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of The Smith Mental Retardation Research Center University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of Pharmacology University of Kansas Medical Center Mail Stop 1018, 3901 Rainbow Blvd Kansas City KS 66160"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies K.","family":"Ozias","sequence":"additional","affiliation":[{"name":"Department of Toxicology University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of Therapeutics University of Kansas Medical Center Kansas City Kansas 66160"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karra A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Toxicology University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of Therapeutics University of Kansas Medical Center Kansas City Kansas 66160"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Toxicology University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of Dietetics &amp; Nutrition University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of Pediatrics University of Kansas Medical Center Kansas City Kansas 66160"},{"name":"Department of The Smith Mental Retardation Research Center University of Kansas Medical Center Kansas City Kansas 66160"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0806-5"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0805-6"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0798-1"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.2.281"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-999-0351-2"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2001130"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00092-X"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10401230009147106"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2000.0196"},{"key":"e_1_2_2_11_1","doi-asserted-by":"crossref","unstructured":"Levant B. 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