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Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolism, our objective was to determine whether the presence of the \u2010516C\/T polymorphism in the <jats:italic>APOB<\/jats:italic> gene promoter could influence postprandial lipoprotein metabolism in healthy subjects. Forty\u2010seven volunteers who were homozygous for the E3 allele at the APOE gene were selected (30 homozygous for the common genotype (C\/C) and 17 heterozygotes for the \u2010516T allele (C\/T). They were given a fat\u2010rich meal containing 1 g fat and 7 mg cholesterol per kg body weight and vitamin A 60,000 IU\/m<jats:sup>2<\/jats:sup> body surface. Fat accounted for 60% of calories, and protein and carbohydrates for 15 and 25% of energy, respectively. Blood samples were taken at time 0, every 1 h until 6 h, and every 2.5 h until 11 h. Total cholesterol and TAGs in plasma, and cholesterol, TAGs and retinyl palmitate in triacylglycerol\u2010rich lipoproteins (large and small triacylglycerol\u2010rich lipoproteins) were determined by ultracentrifugation. Individuals carrying the C\/T genotype presented greater postprandial concentrations of TAGs in small triacylglycerol\u2010rich lipoproteins than did carriers of the C\/C genotype (<jats:italic>P<\/jats:italic> = 0.022). Moreover, C\/T individuals presented higher concentrations of plasma TAGs during the postprandial period than did C\/C subjects (<jats:italic>P<\/jats:italic> = 0.039). No other statistically significant genotype\u2010related differences for other parameters were observed. These results suggest that the presence of the genotype C\/T is associated with a higher postprandial response. Thus, the allele variability in the \u2010516C\/T polymorphism in the <jats:italic>APOB<\/jats:italic> gene promoter may partly explain the interindividual differences in postprandial lipemic response in healthy subjects.<\/jats:p>","DOI":"10.1007\/s11745-007-3027-7","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T07:09:24Z","timestamp":1171004964000},"source":"Crossref","is-referenced-by-count":11,"title":["Postprandial Lipemia is Modified by the Presence of the <i>APOB<\/i>\u2010516C\/T Polymorphism in a Healthy Caucasian Population"],"prefix":"10.1002","volume":"42","author":[{"given":"Pablo","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Unit of Lipids and Atherosclerosis Hospital Universitario Reina Sofia Avda. 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Men\u00e9ndez Pidal, s\/n Cordoba 14004 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Unit of Lipids and Atherosclerosis Hospital Universitario Reina Sofia Avda. Men\u00e9ndez Pidal, s\/n Cordoba 14004 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Moreno","sequence":"additional","affiliation":[{"name":"Unit of Lipids and Atherosclerosis Hospital Universitario Reina Sofia Avda. Men\u00e9ndez Pidal, s\/n Cordoba 14004 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Jim\u00e9nez\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Unit of Lipids and Atherosclerosis Hospital Universitario Reina Sofia Avda. Men\u00e9ndez Pidal, s\/n Cordoba 14004 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Paniagua","sequence":"additional","affiliation":[{"name":"Unit of Lipids and Atherosclerosis Hospital Universitario Reina Sofia Avda. Men\u00e9ndez Pidal, s\/n Cordoba 14004 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"L\u00f3pez\u2010Miranda","sequence":"additional","affiliation":[{"name":"Unit of Lipids and Atherosclerosis Hospital Universitario Reina Sofia Avda. 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