{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:37:35Z","timestamp":1761007055928,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T00:00:00Z","timestamp":1186444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postprandial chylomicrons are potent ultimate acceptors of cell membrane cholesterol and are believed to accelerate reverse cholesterol transport (RCT). We compared the effects of meals rich in polyunsaturated fat (PUFA) and either high (605 mg) or low (151 mg) in cholesterol and a meal rich in dairy fat (DF) in the form of cream on net in vitro transport of red blood cell (RBC) membrane cholesterol to 4 and 6 h postprandial plasma in eight normotriglyceridemic (NTG\u2010H) and eight hypertriglyceridemic (HTG\u2010H) men with mild to moderate hypercholesterolemia. In HTG\u2010H men, cell cholesterol accumulation in 6\u2010h postprandial plasma was significantly (<jats:italic>P<\/jats:italic> = 0.02) less after the PUFA\u2010HC meal compared with the other meals. The significant (<jats:italic>P<\/jats:italic> &lt; 0.001) increase in cell plus endogenous cholesterol accumulation in the triglyceride\u2010rich lipoprotein (TRL) fraction of 4 h postprandial plasma incubated with RBC was significantly (<jats:italic>P<\/jats:italic> = 0.007) higher after the PUFA\u2010HC meal compared with DF meal in HTG\u2010H men. In NTG\u2010H men, cholesterol accumulation in plasma and plasma lipoproteins in the presence and absence of RBC was not significantly affected by the type of meal ingested. These data suggest that addition of large amounts of cholesterol to a PUFA meal may impair diffusion\u2010mediated transport of cell membrane cholesterol to postprandial plasma and that replacing DF with PUFA in a meal increases postprandial lipemia and may potentially increase cholesterol accumulation in atherogenic postprandial TRL in HTG\u2010H men.<\/jats:p>","DOI":"10.1007\/s11745-007-3101-1","type":"journal-article","created":{"date-parts":[[2007,8,6]],"date-time":"2007-08-06T13:17:34Z","timestamp":1186406254000},"page":"901-911","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Dietary Cholesterol and Fat on Cell Cholesterol Transfer to Postprandial Plasma in Hyperlipidemic Men"],"prefix":"10.1002","volume":"42","author":[{"given":"Wayne H. 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