{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:54:19Z","timestamp":1761292459074,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High triacylglycerol (TAG) levels may predict vascular risk. The effect of a statin\u2010induced reduction in TAG levels, irrespective of HDL\u2010C increase, on clinical outcome has not yet been addressed by an endpoint study in patients with coronary heart disease (CHD). The GREACE study compared usual with structured care aimed at achieving LDL\u2010C = 100 mg\/dL (2.6 mmol\/L) by dose titration with atorvastatin. All patients had CHD and were followed for 3 years. This post hoc analysis of GREACE examines the effect of statins on TAG levels and their relation with cardiovascular disease (CVD) events in all patients and in the subgroup of patients with metabolic syndrome (MetS). Baseline TAG levels &gt;150 mg\/dL (1.7 mmol\/L) were predictive of subsequent CVD events [cardiac mortality, non\u2010fatal myocardial infarction (MI), unstable angina (UA), revascularisation, congestive heart failure (CHF), and stroke] only in statin untreated patients. Stepwise regression analysis showed that with every 20% statin\u2010related TAG reduction there was a decrease in CVD risk by 12% (HR 0.88, 95% CI 0.75\u20130.95, <jats:italic>P<\/jats:italic> = 0.007) in the structured care group vs. the usual care group, by 8% (HR 0.92, 95% CI 0.81\u20130.97, <jats:italic>P<\/jats:italic> = 0.02) in all statin treated patients vs. the untreated ones and by 15% (HR 0.85, 95% CI 0.65\u20130.94, <jats:italic>P<\/jats:italic> = 0.005) in those with MetS treated with a statin vs. those untreated. Using the same analysis but only taking into consideration vascular events (cardiac mortality, non\u2010fatal MI, UA, revascularisation, and stroke) there was a 18% (HR = 0.82, 95% CI 0.57\u20130.96, <jats:italic>P<\/jats:italic> = 0.03) decrease in risk in the MetS (+) patients treated with a statin vs. those not on a statin, and a decrease in risk by 16% (HR = 0.84, 95% CI 0.53\u20131.07, <jats:italic>P<\/jats:italic> = 0.08), when only hard vascular endpoints (cardiac mortality, non\u2010fatal MI, and stroke) were considered. TAG levels are predictive of subsequent CVD events in statin untreated CHD patients. Statin (mainly atorvastatin)\u2010induced decrease in TAG levels was related to a significant reduction in subsequent CVD events. This benefit was more pronounced in CHD MetS (+) patients.<\/jats:p>","DOI":"10.1007\/s11745-007-3103-z","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T05:52:24Z","timestamp":1187761944000},"page":"999-1009","source":"Crossref","is-referenced-by-count":22,"title":["Atorvastatin Decreases Triacylglycerol\u2010Associated Risk of Vascular Events in Coronary Heart Disease Patients"],"prefix":"10.1002","volume":"42","author":[{"given":"Vasilios G.","family":"Athyros","sequence":"first","affiliation":[{"name":"Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine Aristotelian University, Hippocration Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna I.","family":"Kakafika","sequence":"additional","affiliation":[{"name":"Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine Aristotelian University, Hippocration Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios A.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine Aristotelian University, Hippocration Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Tziomalos","sequence":"additional","affiliation":[{"name":"Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine Aristotelian University, Hippocration Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Skaperdas","sequence":"additional","affiliation":[{"name":"Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine Aristotelian University, Hippocration Hospital Thessaloniki 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Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri P.","family":"Mikhailidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry (Vascular Prevention Clinics) Royal Free Hospital, Royal Free University College Medical School Pond Street London NW3 2QG UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The GREACE Study Collaborative 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