{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:32:24Z","timestamp":1788323544729,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology, Government of Kerala","doi-asserted-by":"publisher","award":["IR\/SO\/LF\u201003\/2006"],"award-info":[{"award-number":["IR\/SO\/LF\u201003\/2006"]}],"id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atorvastatin calcium (AC) is a second\u2010generation 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010CoA reductase inhibitor approved for clinical use as a lipid lowering agent. AC, the world's best selling drug is associated with poor oral bioavailability and serious adverse effects like rhabdomyolysis on chronic administration. A biodegradable nanoparticulate approach was introduced here with a view to improving the efficacy and safety of AC. Poly lactide\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid (PLGA) nanoparticles containing atorvastatin calcium were prepared using two stabilizers i.e. didodecyl dimethyl ammonium bromide (DMAB) and Vitamin E tocopheryl polyethylene glycol 1000 succinate (Vit E\u2010TPGS) using a co\u2010solvent approach by emulsion\u2013diffusion\u2013evaporation method. AC loaded PLGA nanoparticles prepared using DMAB and Vit E\u2010TPGS were found to be 120.0 \u00b1 4.2 nm and 140.0 \u00b1 1.5 nm (z\u2010average) in size respectively. In vitro release studies at pH 7.4 revealed a zero order release profile for nanoparticles. Efficacy and safety parameters of the prepared nanoparticles against marketed formulation were evaluated in high fat diet fed (hyperlipidemic) rats. It was found that atorvastatin calcium nanoparticles were equally effective in comparison to Lipicure<jats:sup>\u00ae<\/jats:sup>, at a 66%\u2010reduced dose in treating the hyperlipidemia characterized by alterations in PTC, LDL\u2010C, VLDL\u2010C, HDL\u2010C, PTG and PGL in the high fat diet fed rats. On the other hand, when evaluated for safety, nanoparticulate formulation showed no\/negligible myotoxicity characterized by lower PC, BUN, CK, LDH and AST levels in comparison to the marketed formulation.<\/jats:p>","DOI":"10.1007\/s11745-007-3142-5","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T05:20:41Z","timestamp":1199856041000},"page":"231-241","source":"Crossref","is-referenced-by-count":36,"title":["Oral Nanoparticulate Atorvastatin Calcium is More Efficient and Safe in Comparison to Lipicure<sup>\u00ae<\/sup> in Treating Hyperlipidemia"],"prefix":"10.1002","volume":"43","author":[{"given":"A. K.","family":"Meena","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER) Phase\u2010X, S. A. S. Nagar Punjab 160062 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Venkat","family":"Ratnam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER) Phase\u2010X, S. A. S. Nagar Punjab 160062 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chandraiah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER) Phase\u2010X, S. A. S. Nagar Punjab 160062 India"},{"name":"Center for Pharmaceutical Nanotechnology National Institute of Pharmaceutical Education and Research (NIPER) Phase\u2010X, S. A. S. Nagar Punjab 160062 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Ankola","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER) Phase\u2010X, S. A. S. 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Nagar Punjab 160062 India"},{"name":"Center for Pharmaceutical Nanotechnology National Institute of Pharmaceutical Education and Research (NIPER) Phase\u2010X, S. A. S. 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