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We used different doses of CLA and examined effects on renal histological benefit, the renal PPAR\u03b3 system and hepatic and renal levels of CLA isomers. Male and female offspring of Han:SPRD<jats:italic>\u2010cy<\/jats:italic> heterozygotes were fed diets with 0, 1 or 2% CLA isomer mixture for 12 weeks before dual\u2010energy X\u2010ray absorptiometry, harvest of renal and hepatic tissue for histologic and lipid analysis. Both CLA diets reduced body fat content in both genders but did not change lean body mass. CLA produced a dose dependent reduction in female renal cystic change. CLA reduced fibrosis, but this reduction was significantly less with higher dose in males. CLA reduced macrophage infiltration, tissue oxidized LDL content and proliferation of epithelial cells. Serum creatinine rose significantly in female animals fed CLA diets. CLA treatment did not change PPAR\u03b3 activation. A significant negative correlation with renal content of the 18:2 c9,t11 isomer and the sum of histologic effects was identified. CLA reduces histologic renal injury in the Han:SPRD<jats:italic>\u2010cy<\/jats:italic> rat model probably inversely proportionate to c9,t11 renal content. Possible functional CLA toxicity at high dose in female animals warrants further exploration.<\/jats:p>","DOI":"10.1007\/s11745-008-3211-4","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T10:35:54Z","timestamp":1216118154000},"page":"783-791","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Conjugated Linoleic Acid Renal Benefits and Possible Toxicity vary with Isomer, Dose and Gender in Rat Polycystic Kidney Disease"],"prefix":"10.1002","volume":"43","author":[{"given":"Malcolm R.","family":"Ogborn","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health University of Manitoba JBRC513\u2010715 McDermot Avenue Winnipeg MB R3C 3P4 Canada"},{"name":"Department of Human Nutritional Sciences University of Manitoba Winnipeg MB Canada"},{"name":"9\u2010386 3333 University Way Prince George BC V2N 4Z9 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