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It was therefore hypothesized that C57BL\/6 and DBA\/2 mice exhibit constitutive differences in brain DHA composition that are independent of diet. To test this, adult C57BL\/6J and DBA\/2J prefrontal cortex, hippocampus, ventral striatum, and midbrain fatty acid composition was determined by gas chromatography. After correction for multiple comparisons, C57BL\/6J mice exhibited significantly lower DHA composition in the hippocampus and ventral striatum, but not prefrontal cortex or midbrain, and significantly greater regional arachidonic acid (ARA, 20:4n\u20106):DHA ratios, relative to DBA\/2J mice. C57BL\/6J mice also exhibited significantly lower regional adrenic acid (ADA, 22:4n\u20106) composition, and a significantly smaller ADA:ARA ratio, relative to DBA\/2J mice. C57BL\/6J mice exhibited significantly smaller oleic acid:stearic acid ratio in the hippocampus and ventral striatum relative to DBA\/2J mice. Among all mice, DHA composition was positively correlated with the ADA:ARA ratio and inversely correlated with the oleic acid:stearic acid ratio. These data demonstrate that inbred C57BL\/6J and DBA\/2J mouse strains exhibit constitutive and region\u2010specific differences in fatty acid composition independent of diet, and suggest that heritable genetic factors are an important determinant of central fatty acid composition.<\/jats:p>","DOI":"10.1007\/s11745-008-3244-8","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T03:14:10Z","timestamp":1224040450000},"page":"1-8","source":"Crossref","is-referenced-by-count":20,"title":["Inbred C57BL\/6J and DBA\/2J Mouse Strains Exhibit Constitutive Differences in Regional Brain Fatty Acid Composition"],"prefix":"10.1002","volume":"44","author":[{"given":"Robert K.","family":"McNamara","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Cincinnati College of Medicine 231 Albert Sabin Way Cincinnati OH 45267\u20100516 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