{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:28:40Z","timestamp":1791808120013,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS055195"],"award-info":[{"award-number":["NS055195"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sandhoff disease (SD) is a glycosphingolipid (GSL) storage disease that arises from an autosomal recessive mutation in the gene for the \u03b2\u2010subunit of \u03b2\u2010Hexosaminidase A (\n                    <jats:italic>Hexb<\/jats:italic>\n                    gene), which catabolizes ganglioside GM2 within lysosomes. Accumulation of GM2 and asialo\u2010GM2 (GA2) occurs primarily in the CNS, leading to neurodegeneration and brain dysfunction. We analyzed the total lipids in the brains of SD mice, cats, and humans. GM2 and GA2 were mostly undetectable in the normal mouse, cat, and human brain. The lipid abnormalities in the SD cat brain were generally intermediate to those observed in the SD mouse and the SD human brains. GM2 comprised 38, 67, and 87% of the total brain ganglioside distribution in the SD mice, cats, and humans, respectively. The ratio of GA2\u2013GM2 was 0.93, 0.13, and 0.27 in the SD mice, cats, and humans, respectively, suggesting that the relative storage of GA2 is greater in the SD mouse than in the SD cat or human. Finally, the myelin\u2010enriched lipids, cerebrosides and sulfatides, were significantly lower in the SD brains than in the control brains. This study is the first comparative analysis of brain lipids in mice, cats, and humans with SD and will be important for designing therapies for Sandhoff disease patients.\n                  <\/jats:p>","DOI":"10.1007\/s11745-008-3268-0","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T12:59:22Z","timestamp":1228309162000},"page":"197-205","source":"Crossref","is-referenced-by-count":48,"title":["Comparative Analysis of Brain Lipids in Mice, Cats, and Humans with Sandhoff Disease"],"prefix":"10.1002","volume":"44","author":[{"given":"Rena C.","family":"Baek","sequence":"first","affiliation":[{"name":"Biology Department Boston College Chestnut Hill MA 02467 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Scott\u2010Ritchey Research Center and Department of Pathobiology College of Veterinary Medicine, Auburn University Auburn AL 36849 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