{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:59:25Z","timestamp":1791338365861,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DEO 14678"],"award-info":[{"award-number":["T32DEO 14678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DEO 07288"],"award-info":[{"award-number":["T32DEO 07288"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DEO18032"],"award-info":[{"award-number":["R01 DEO18032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ceramides are the major type of lipid found in stratum corneum from the skin, gingiva and hard palate. The present study examined the ceramides of the stratum corneum from the hard palate. Six fractions of ceramides were isolated by preparative thin\u2010layer chromatography. The least polar fraction contained an unusual acyl ceramide (EOS) consisting of long \u03c9\u2010hydroxy acids amide\u2010linked to sphingosine with mostly saturated fatty acids ester\u2010linked to the \u03c9\u2010hydroxyl group. The second and third fractions contained normal fatty acids amide\u2010linked to sphingosine (NS) and phytosphingosine (NP), respectively. In each of these ceramides, the fatty acids consisted of a mixture of saturated and monoenoic species. The three most polar fractions all contain amide\u2010linked \u03b1\u2010hydroxy acids. The fourth fraction contained long \u03b1\u2010hydroxy acids amide\u2010linked to sphingosine (ASl), while the fifth fraction contained short \u03b1\u2010hydroxy acids amide\u2010linked to sphingosine (ASs). The most polar ceramide contained \u03b1\u2010hydroxy acids amide\u2010linked to phytosphingosine (AP). EOS, NS and NP differed from their epidermal counterparts in terms of the compositions of the normal fatty acids. ASl, ASs and AP from palatal stratum corneum were essentially identical to their epidermal counterparts. The differences between palatal and epidermal EOS, NS and NP contribute to the differences in permeability of palate compared to skin.<\/jats:p>","DOI":"10.1007\/s11745-009-3283-9","type":"journal-article","created":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T11:42:06Z","timestamp":1233142926000},"page":"291-295","source":"Crossref","is-referenced-by-count":18,"title":["Structures of the Ceramides from Porcine Palatal Stratum Corneum"],"prefix":"10.1002","volume":"44","author":[{"given":"Jennifer R.","family":"Hill","sequence":"first","affiliation":[{"name":"University of Minnesota Minneapolis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Wertz","sequence":"additional","affiliation":[{"name":"University of Iowa N450 DSB Iowa City IA 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume-title":"Oral mucosal drug delivery","author":"Wertz PW","year":"1996"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00091-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12499809"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90135-N"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(81)90006-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12515931"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555741214"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(97)00108-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37950-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37949-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH9600080"},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Lipids and barrier function of the skin","volume":"208","author":"Wertz PW","year":"2000","journal-title":"Acta Derm Venerol"},{"key":"e_1_2_6_14_1","volume-title":"Life on earth","author":"Attenborough D","year":"1980"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12336024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(98)00053-4"},{"key":"e_1_2_6_17_1","first-page":"23","article-title":"The lipid organization in the skin barrier","volume":"208","author":"Bouwstra JA","year":"2000","journal-title":"Acta Derm Venereol Suppl"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(03)00238-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R700016-JLR200"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-009-3283-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:36:03Z","timestamp":1760956563000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-009-3283-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,29]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1007\/s11745-009-3283-9"],"URL":"https:\/\/doi.org\/10.1007\/s11745-009-3283-9","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,29]]}}}