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In mice, treatment with SPS and PS inhibited histamine\u2010induced scratching behavior and vascular permeability. These agents inhibited the expression of the allergic cytokines, IL\u20104 and TNF\u2010\u03b1, and the activation of the transcription factors, NF\u2010\u03baB and c\u2010jun, in histamine\u2010stimulated skin tissues. These agents also showed potent anti\u2010histamine effects in the Magnus test using guinea pig ileum. Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF\u2010\u03baB and c\u2010jun.<\/jats:p>","DOI":"10.1007\/s11745-010-3441-0","type":"journal-article","created":{"date-parts":[[2010,6,28]],"date-time":"2010-06-28T05:23:56Z","timestamp":1277702636000},"page":"613-618","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010scratching Behavioral Effects of <i>N<\/i>\u2010Stearoyl\u2010phytosphingosine and 4\u2010Hydroxysphinganine in Mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Kwon\u2010Ryeol","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Department of Pharmaceutical Science College of Pharmacy, Kyung Hee University 1, Hoegi, Dongdaemun\u2010ku Seoul 130\u2010701 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