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Essential fatty acids (EFA) (n\u20103) have been reported by their antioxidant and neuroprotective properties, and therefore the influence of the FO supplementation on the reserpine\u2010induced motor disorders was studied. Wistar rats were orally treated with FO solution for 5 days, and co\u2010treated with reserpine (<jats:italic>R<\/jats:italic>; 1 mg\/kg\/mL) or its vehicle for 3 days (every other day). Reserpine\u2010induced orofacial dyskinesia and catalepsy (<jats:italic>P<\/jats:italic> &lt; 0.05) were prevented by FO (<jats:italic>P<\/jats:italic> &lt; 0.05). Biochemical evaluations showed that reserpine treatment increased the lipid peroxidation in the cortex and striatum (<jats:italic>P<\/jats:italic> &lt; 0.05), while the FO supplementation prevented this oxidative effect in both brain regions (<jats:italic>P<\/jats:italic> &lt; 0.05). Our results showed the protective role of FO in the brain lipid membranes, reinforcing the beneficial effect of n\u20103 fatty acids in the prevention of degenerative and motor disorders.<\/jats:p>","DOI":"10.1007\/s11745-010-3514-0","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T13:38:45Z","timestamp":1292420325000},"page":"143-149","source":"Crossref","is-referenced-by-count":17,"title":["Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine\u2010Induced Parkinsonism in Rats"],"prefix":"10.1002","volume":"46","author":[{"given":"Raquel Cristine Silva","family":"Barcelos","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia, Centro de Ci\u00eancias da Sa\u00fade Universidade Federal de Santa Maria (UFSM) Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila 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