{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:11:39Z","timestamp":1771881099756,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T00:00:00Z","timestamp":1297728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to compare the efficacy of high\u2010dose rosuvastatin, low\u2010dose rosuvastatin plus fenofibrate and low\u2010dose rosuvastatin plus omega\u20103 fatty acids with regard to the lipid profile in patients with mixed hyperlipidemia. The primary endpoint was changes in non\u2010high density lipoprotein\u2010cholesterol (non\u2010HDL\u2010C) levels. Study participants were randomly allocated to receive rosuvastatin 40 mg (<jats:italic>n<\/jats:italic> = 30, R group), rosuvastatin 10 mg plus fenofibrate 200 mg (<jats:italic>n<\/jats:italic> = 30, RF group) or rosuvastatin 10 mg plus n\u20103 fatty acids 2 g (<jats:italic>n<\/jats:italic> = 30, RN group). Non\u2010HDL\u2010C levels were reduced in all groups: in R group by 54%, in RF group by 42% and in RN group by 42%. Significant reductions in total cholesterol (TC), low density lipoprotein (LDL)\u2010C and triglyceride levels were observed in all groups. The reductions in total and LDL\u2010C were greatest in the R group while a more pronounced reduction of triglycerides in the RF group compared with that in the R and the RN group was observed. HDL\u2010C levels were significantly increased only in the RF group. In conclusion, high doses of rosuvastatin and small doses of rosuvastatin plus either fenofibrate or n\u20103 fatty acids exhibit favorable effects on both LDL\u2010C and non\u2010HDL\u2010C levels. However, rosuvastatin monotherapy more potently reduces these parameters. The combination of rosuvastatin plus fenofibrate leads to a greater decrease in triglyceride levels and a greater increase in HDL\u2010C levels compared with the other two treatments. While awaiting the results of ongoing trials high doses of rosuvastatin may represent the treatment of choice in individuals with mixed dyslipidemia.<\/jats:p>","DOI":"10.1007\/s11745-011-3538-0","type":"journal-article","created":{"date-parts":[[2011,2,14]],"date-time":"2011-02-14T00:18:03Z","timestamp":1297642683000},"page":"521-528","source":"Crossref","is-referenced-by-count":17,"title":["High Doses of Rosuvastatin are Superior to Low Doses of Rosuvastatin Plus Fenofibrate or n\u20103 Fatty Acids in Mixed Dyslipidemia"],"prefix":"10.1002","volume":"46","author":[{"given":"A. P.","family":"Agouridis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical School University of Ioannina Ioannina 45110 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Tsimihodimos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School University of Ioannina Ioannina 45110 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. D.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School University of Ioannina Ioannina 45110 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Tselepis","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Chemistry University of Ioannina Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Elisaf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School University of Ioannina Ioannina 45110 Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14234-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.10.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125002405"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.jpc60002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X112462"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125000516"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125001668"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.084"},{"key":"e_1_2_6_12_1","first-page":"223","article-title":"Beneficial effects of omega\u20103 fatty acids: the current evidence","volume":"47","author":"Gazi I","year":"2006","journal-title":"Hellenic J Cardiol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.07.018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"e_1_2_6_15_1","volume-title":"A practical approach.","author":"Pocock SJ","year":"1983"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380200073024"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/107424840501000106"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.532499"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.024"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.12.1585"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.03.024"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.04.070"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67667-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161052773942"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02101.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.10.008"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005258"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1305-z"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.540"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.08.005"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-011-3538-0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s11745-011-3538-0","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-011-3538-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:45:01Z","timestamp":1760949901000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-011-3538-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,15]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1007\/s11745-011-3538-0"],"URL":"https:\/\/doi.org\/10.1007\/s11745-011-3538-0","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,15]]}}}