{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:41:56Z","timestamp":1791117716624,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T00:00:00Z","timestamp":1304380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diacylglycerol acyltransferase (DGAT) catalyzes the final step of triacylglycerol (TAG) synthesis, and is considered as a potential target to control hypertriglyceridemia or other metabolic disorders. In this study, we found that the extract of rose petals suppressed TAG synthesis in cultured cells, and that the extract showed DGAT inhibitory action in a dose\u2010dependent manner. Fractionation of the rose extract revealed that the DGAT inhibitory substances in the extract were ellagitannins; among them rugosin B, and D, and eusupinin A inhibited DGAT activity by 96, 82, and 84% respectively, at 10 \u03bcM. These substances did not inhibit the activities of other hepatic microsomal enzymes, glucose\u20106\u2010phosphatase and HMG\u2010CoA reductase, or pancreatic lipase, suggesting that ellagitannins inhibit DGAT preferentially. In an oral fat load test using mice, postprandial plasma TAG increase was suppressed by rose extract; TAG levels 2 h after the fat load were significantly lower in mice administered a fat emulsion containing rose extract than in control mice (446.3 \u00b1 33.1 vs 345.3 \u00b1 25.0 mg\/dL, control vs rose extract group; <jats:italic>P<\/jats:italic> &lt; 0.05). These results suggest that rose ellagitannins or rose extract could be beneficial in controlling lipid metabolism and used to improve metabolic disorders.<\/jats:p>","DOI":"10.1007\/s11745-011-3559-8","type":"journal-article","created":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T17:49:12Z","timestamp":1304358552000},"page":"691-700","source":"Crossref","is-referenced-by-count":14,"title":["Identification of Diacylglycerol Acyltransferase Inhibitors from <i>Rosa centifolia<\/i> Petals"],"prefix":"10.1002","volume":"46","author":[{"given":"Hidehiko","family":"Kondo","sequence":"first","affiliation":[{"name":"Biological Science Laboratories Kao Corporation 2606 Akabane, Ichikai\u2010machi, Haga\u2010gun Tochigi 321\u20103497 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohjiro","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Biological Science Laboratories Kao Corporation 2606 Akabane, Ichikai\u2010machi, Haga\u2010gun Tochigi 321\u20103497 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Biological Science Laboratories Kao Corporation 2606 Akabane, Ichikai\u2010machi, Haga\u2010gun Tochigi 321\u20103497 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Hase","sequence":"additional","affiliation":[{"name":"Biological Science Laboratories Kao Corporation 2606 Akabane, Ichikai\u2010machi, Haga\u2010gun Tochigi 321\u20103497 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Murase","sequence":"additional","affiliation":[{"name":"Biological Science Laboratories Kao Corporation 2606 Akabane, Ichikai\u2010machi, Haga\u2010gun Tochigi 321\u20103497 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/21.9.904"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1985.tb08848.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90296-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-8902.2003.0310.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.7.723"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90085-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.25.2519"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00364-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027569.76671.A8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-12-200412210-00011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.002331"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(96)00005-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202013200"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/75651"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214672"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.01.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.942"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)00157-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.05.020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815534"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2006.tb12404.x"},{"key":"e_1_2_6_23_1","first-page":"123","article-title":"Spectrum of antibacterial activity possessed by petals of rose varieties","volume":"77","author":"Darokar MP","year":"1999","journal-title":"Curr Sci"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.100.3.965"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1139\/y59-099"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0600604"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(02)00026-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.122"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802141"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020031"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.3.582"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.1.110"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)89087-1"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.30.4230"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.3308"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.30.4234"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.3341"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.39.881"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70645"},{"key":"e_1_2_6_41_1","first-page":"37","article-title":"Antitumor activity and interleukin\u20101 induction by tannins","volume":"13","author":"Miyamoto K","year":"1993","journal-title":"Anticancer Res"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.08.006"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.542"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2004.tb03521.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802926"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36358"},{"key":"e_1_2_6_47_1","first-page":"258","article-title":"In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens","volume":"702","author":"Chung MY","year":"2004","journal-title":"Planta Med"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300403-JLR200"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.2.155"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207353200"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9904607"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.5.1108"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.1.3"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118742"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)42012-7"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.2.E241"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-011-3559-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:01:55Z","timestamp":1760965315000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-011-3559-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,3]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1007\/s11745-011-3559-8"],"URL":"https:\/\/doi.org\/10.1007\/s11745-011-3559-8","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,3]]}}}