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Probucol is a hypocholesterolemic agent that reduces amyloid burden in transgenic amyloid mice, but the mechanisms for this effect are presently unclear. In this study, the effect of Probucol on intestinal lipoprotein\u2010A\u03b2 homeostasis was explored. Wild\u2010type mice were fed a control low\u2010fat diet and enterocytic A\u03b2 was stimulated by high\u2010fat (HF) diet enriched in 10% (w\/w) saturated fat and 1% (w\/w) cholesterol for the duration of 1 month. Mice treated with Probucol had the drug incorporated into the chow at 1% (w\/w). Quantitative immunofluorescence was utilised to determine intestinal apolipoprotein B (apo B) and A\u03b2 abundance. We found apo B in both the perinuclear region of the enterocytes and the lacteals in all groups. However, HF feeding and Probucol treatment increased secretion of apo B into the lacteals without any change in net villi abundance. On the other hand, HF\u2010induced enterocytic perinuclear A\u03b2 was significantly attenuated by Probucol. No significant changes in A\u03b2 were observed within the lacteals. The findings of this study support the notion that Probucol suppresses dietary fat induced stimulation of A\u03b2 biosynthesis and attenuate availability of apo B lipoprotein\u2010A\u03b2 for secretion.<\/jats:p>","DOI":"10.1007\/s11745-011-3595-4","type":"journal-article","created":{"date-parts":[[2011,7,30]],"date-time":"2011-07-30T02:18:57Z","timestamp":1311992337000},"page":"27-34","source":"Crossref","is-referenced-by-count":29,"title":["Probucol Suppresses Enterocytic Accumulation of Amyloid\u2010\u03b2 Induced by Saturated Fat and Cholesterol Feeding"],"prefix":"10.1002","volume":"47","author":[{"given":"Menuka M.","family":"Pallebage\u2010Gamarallage","sequence":"first","affiliation":[{"name":"School of Public Health Curtin University of Technology GPO Box U1987 Perth WA 6845 Australia"},{"name":"Australian Technology Network Centre for Metabolic Fitness Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Galloway","sequence":"additional","affiliation":[{"name":"School of Public Health Curtin University of Technology GPO Box U1987 Perth WA 6845 Australia"},{"name":"Australian Technology Network Centre for Metabolic Fitness Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Takechi","sequence":"additional","affiliation":[{"name":"School of Public Health Curtin University of Technology GPO Box U1987 Perth WA 6845 Australia"},{"name":"Australian Technology Network Centre for Metabolic Fitness Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvinder","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"School of Public Health Curtin University of Technology GPO Box U1987 Perth WA 6845 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C. 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