{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:59:15Z","timestamp":1766048355629,"version":"build-2065373602"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:00:00Z","timestamp":1348704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the present work was to study the renal function of healthy and tumor\u2010bearing rats chronically supplemented with fish oil (FO), a source of n\u20103 polyunsaturated fatty acids. Weanling male rats were divided in two groups, one control (C) and another orally supplemented for 70 days with FO (1 g\/kg body weight). After this time, half the animals of each group were injected in the right flank with a suspension of Walker 256 tumor cells (W and WFO). The W group had less proteinemia reflecting cachectic proteolysis, FO reversed this fact. Tumor weight gain was also reduced in WFO. Glomerular filtration rate (GFR) was not different in FO or W compared to C, but was higher in WFO. Renal plasma flow (RPF) was higher in the FO supplemented groups. The W group had lower plasma osmolality than the C group, but FO supplementation resulted in normalization of this parameter. Fractional sodium excretion (FE<jats:sub>Na+<\/jats:sub>) of FO rats was similar to C. Proximal Na<jats:sup>+<\/jats:sup> reabsorption, evaluated by lithium clearance, was similar among the groups. Urinary thromboxane B<jats:sub>2<\/jats:sub> (TXB<jats:sub>2<\/jats:sub>) excretion was lower in the supplemented groups. The number of macrophages in renal tissue was higher in W compared to C rats, but was lower in WFO rats compared to W rats. In conclusion, FO supplementation resulted in less tumor growth and cachexia, and appeared to be renoprotective, as suggested by higher RPF and GFR.<\/jats:p>","DOI":"10.1007\/s11745-012-3715-9","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T11:17:38Z","timestamp":1348658258000},"page":"1031-1041","source":"Crossref","is-referenced-by-count":10,"title":["Fish Oil Supplementation Reduces Cachexia and Tumor Growth While Improving Renal Function in Tumor\u2010Bearing Rats"],"prefix":"10.1002","volume":"47","author":[{"given":"Isabela","family":"Coelho","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia, Setor de Ci\u00eancias Biol\u00f3gicas Universidade Federal do Paran\u00e1 (UFPR) Centro Polit\u00e9cnico s\/n.\u2013Jd. das Am\u00e9ricas Post Box 19031 Curitiba PR 81531\u2010990 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Casare","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Setor de Ci\u00eancias Biol\u00f3gicas Universidade Federal do Paran\u00e1 (UFPR) Centro Polit\u00e9cnico s\/n.\u2013Jd. das Am\u00e9ricas Post Box 19031 Curitiba PR 81531\u2010990 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle C. 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