{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:30:42Z","timestamp":1765827042689,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relevance of serum apolipoprotein E (apoE) levels to two hypertriglyceridemic dyslipidemias has not been clarified. We explored, in a cross\u2010sectional (and short\u2010term prospective) evaluation, the independent relationship of serum apoE to the atherogenic dyslipidemia, hypertriglyceridemia with elevated apoB (HtgB) and to apoA\u2010I dysfunctionality, previously shown in Turkish adults to be independent of apoE genotype. Serum apoE concentrations were measured by immunonephelometry in 1,127 middle\u2010aged adults. In multivariable regression analysis, apoE concentrations showed log\u2010linear associations with apoB and apoA\u2010I levels, waist circumference, independent of C\u2010reactive protein (CRP), homeostatic model assessment (HOMA) index and other confounders. The likelihood of atherogenic dyslipidemia and of HtgB roughly tripled per 1\u2010SD increment in apoE concentrations, additively to apoE genotype, HOMA, apoA\u2010I, CRP concentrations and waist circumference; yet apoA\u2010I, protective against atherogenic dyslipidemia, appeared to promote HtgB, a finding consistent with apoA\u2010I dysfunctionality in this setting. Each 1\u2010SD increment in the apoE level was moreover, associated in both genders with MetS (at OR 1.5), after adjustment for sex, age, apoB, apoA\u2010I and CRP, or for apoE genotypes. Circulating apoE predicted in both genders age\u2010adjusted prevalent and incident coronary heart disease (CHD), independent of apoE genotype and CRP (OR 1.32 [95 % CI 1.11; 1.58]). To conclude, in a general population prone to MetS, elevated apoE concentrations are strongly linked to HtgB and atherogenic dyslipidemia, irrespective of apoE genotype, are associated with MetS and CHD. Excess apoE reflects pro\u2010inflammatory state and likely autoimmune activation.<\/jats:p>","DOI":"10.1007\/s11745-012-3724-8","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T01:16:09Z","timestamp":1351041369000},"page":"51-61","source":"Crossref","is-referenced-by-count":7,"title":["High Serum Apolipoprotein E Determines Hypertriglyceridemic Dyslipidemias, Coronary Disease and ApoA\u2010I Dysfunctionality"],"prefix":"10.1002","volume":"48","author":[{"given":"Altan","family":"Onat","sequence":"first","affiliation":[{"name":"Turkish Society of Cardiology Nisbetiye cad. 59\/24 Istanbul Etiler 34335 Turkey"},{"name":"Cerrahpa\u015fa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnay","family":"Can","sequence":"additional","affiliation":[{"name":"Cerrahpa\u015fa Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ender","family":"\u00d6rnek","sequence":"additional","affiliation":[{"name":"Etlik Ihtisas Education Hospital Ankara Etlik Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Cardiology Department, Medical Faculty Bal\u0131kesir University Bal\u0131kesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihan","family":"Erginel\u2010\u00dcnaltuna","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institute for Experimental Medical Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sani N.","family":"Murat","sequence":"additional","affiliation":[{"name":"Etlik Ihtisas Education Hospital Ankara Etlik Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)33334-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41611-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.11.1300"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011111"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32833af368"},{"key":"e_1_2_9_7_1","first-page":"449","article-title":"Serum apolipoprotein E concentrations among Turks: additive information to genotype relative to dyslipidemia and metabolic syndrome","volume":"35","author":"Onat A","year":"2007","journal-title":"Arch Turk Soc Cardiol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.01.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030176"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039110"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.05.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.04.018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.12.066"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.09.023"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.526848"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.181735"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00500-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.012"},{"key":"e_1_2_9_20_1","first-page":"3160","article-title":"Expert committee on the diagnosis and classification of diabetes mellitus. 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