{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:27:56Z","timestamp":1761006476531,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007807","name":"Japan Science Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From an enzyme kinetic study using rat liver microsomes, \u03b1\u2010tocopherol has been suggested to accelerate the other vitamin E catabolism by stimulating vitamin E \u03c9\u2010hydroxylation, the late limiting reaction of the vitamin E catabolic pathway. To test the effect of \u03b1\u2010tocopherol on catabolism of the other vitamin E isoforms in vivo, we determined whether \u03b1\u2010tocopherol accelerates depletion of \u03b3\u2010tocopherol and tocotrienol and excretion of their metabolites in rats. Male Wistar rats were fed a \u03b3\u2010tocopherol\u2010rich diet for 6 weeks followed by a \u03b3\u2010tocopherol\u2010free diet with or without \u03b1\u2010tocopherol for 7 days. Intake of \u03b3\u2010tocopherol\u2010free diets lowered \u03b3\u2010tocopherol concentrations in serum, liver, adrenal gland, small intestine, and heart, but there was no effect of dietary \u03b1\u2010tocopherol on \u03b3\u2010tocopherol concentrations. The level of urinary excretion of \u03b3\u2010tocopherol metabolite was not affected by dietary \u03b1\u2010tocopherol. Next, the effect of \u03b1\u2010tocopherol on tocotrienol depletion was examined using rats fed a tocotrienol\u2010rich diet for 6 weeks. Subsequent intake of a tocotrienol\u2010free diet with or without \u03b1\u2010tocopherol for 7 days depleted concentrations of \u03b1\u2010 and \u03b3\u2010tocotrienol in serum and tissues, which was accompanied by a decrease in the excretion of \u03b3\u2010tocotrienol metabolite. However, neither the tocotrienol concentration nor \u03b3\u2010tocotrienol metabolite excretion was affected by dietary \u03b1\u2010tocopherol. These data showed that dietary \u03b1\u2010tocopherol did not accelerate the depletion of \u03b3\u2010tocopherol and tocotrienol and their metabolite excretions, suggesting that the positive effect of \u03b1\u2010tocopherol on vitamin E \u03c9\u2010hydroxylase is not sufficient to affect the other isoform concentrations in tissues.<\/jats:p>","DOI":"10.1007\/s11745-013-3796-0","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T02:49:57Z","timestamp":1369190997000},"page":"687-695","source":"Crossref","is-referenced-by-count":4,"title":["\u03b1\u2010Tocopherol does not Accelerate Depletion of \u03b3\u2010Tocopherol and Tocotrienol or Excretion of their Metabolites in Rats"],"prefix":"10.1002","volume":"48","author":[{"given":"Tomono","family":"Uchida","sequence":"first","affiliation":[{"name":"Department of Home Economics Aichi Gakusen University Okazaki 444\u20108520 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Nagoya University of Arts and Sciences 57 Takenoyama, Iwasaki Nisshin 470\u20100196 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Nagoya University of Arts and Sciences 57 Takenoyama, Iwasaki Nisshin 470\u20100196 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Hanzawa","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Nagoya University of Arts and Sciences 57 Takenoyama, Iwasaki Nisshin 470\u20100196 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Nagoya University of Arts and 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