{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:04:10Z","timestamp":1789650250575,"version":"4.0.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that n\u20103 polyunsaturated fatty acids n\u20103 (n\u20103 PUFA) have several anticancer effects, especially attributed to their ability to modulate a variety of genomic and immune responses. In this context, this randomized, prospective, controlled clinical trial was conducted in order to check whether supplementation of 2 g\/day of fish oil for 9 weeks alters the production of inflammatory markers, the plasma fatty acid profile and the nutritional status in patients with colorectal cancer (CRC). Eleven adults with CRC in chemotherapy were randomized into two groups: (a) supplemented (SG) daily with 2 g\/day of encapsulated fish oil [providing 600 mg\/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA)] for 9 weeks (<jats:italic>n<\/jats:italic> = 6), and (b) control (CG) (<jats:italic>n<\/jats:italic> = 5). All outcomes were evaluated on the day before the first chemotherapy session and 9 weeks later. Plasma TNF\u2010\u03b1, IL\u20101\u03b2, IL\u201010 and IL\u201017A, the pro\/anti\u2010inflammatory balance (ratio TNF\u2010\u03b1\/IL\u201010 and IL\u20101\u03b2\/IL10) and serum albumin, showed no significant changes between times and study groups (<jats:italic>p<\/jats:italic> &gt; 0.05). C\u2010reactive protein (CRP) and the CRP\/albumin ratio showed opposite behavior in groups, significantly reducing their values in SG (<jats:italic>p<\/jats:italic> &lt; 0.05). Plasma proportions of EPA and DHA increased 1.8 and 1.4 times, respectively, while the ARA reduced approximately 0.6 times with the supplementation (9 weeks vs baseline, <jats:italic>p<\/jats:italic> &lt; 0.05). Patients from SG gained 1.2 kg (median) while the CG lost \u22120.5 kg (median) during the 9 weeks of chemotherapy (<jats:italic>p<\/jats:italic> = 0.72). These results demonstrate that 2 g\/day of fish oil for 9 weeks of chemotherapy improves CRP values, CRP\/albumin status, plasma fatty acid profile and potentially prevents weight loss during treatment.<\/jats:p>","DOI":"10.1007\/s11745-013-3816-0","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T12:25:41Z","timestamp":1374755141000},"page":"879-888","source":"Crossref","is-referenced-by-count":79,"title":["Fish Oil Decreases C\u2010Reactive Protein\/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients"],"prefix":"10.1002","volume":"48","author":[{"given":"Michel Carlos","family":"Mocellin","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program of Nutrition, Department of Nutrition Federal University of Santa Catarina Reitor Jo\u00e3o David Ferreira Lima Campus, Trindade Florian\u00f3polis SC 88040\u2010970 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