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The <jats:italic>pcy<\/jats:italic> mouse is an orthologous model of human NPHP, with a mutation in the <jats:italic>Nphp3<\/jats:italic> gene. Renal phospholipase A<jats:sub>2<\/jats:sub>, cyclooxygenase (COX) 1 and cyclic AMP are elevated in this model, suggesting that eicosanoid formation may be altered. In another type of PKD observed in the Han:SPRD\u2010<jats:italic>Cy<\/jats:italic> rat, inhibition of eicosanoid production slows disease progression. If renal eicosanoids are similarly altered in NPHP, potential for pharmacologic intervention also may exist for this disorder. Therefore, renal fatty acids and eicosanoids were determined in <jats:italic>pcy<\/jats:italic> and normal mice at 15, 30 and 60 days of age by gas chromatography and HPLC\u2013tandem mass spectrometry, respectively. Renal cysts in enlarged kidneys were observed in <jats:italic>pcy<\/jats:italic> mice by 15 days of age and increased over time. Renal phospholipid ARA levels were higher in <jats:italic>pcy<\/jats:italic> compared to normal mice at 15 and 30 days. Eicosanoid differences were observed starting at 30 days, when the COX products 6\u2010keto\u2010prostaglandin (PG) F<jats:sub>1\u03b1<\/jats:sub>, thromboxane B<jats:sub>2<\/jats:sub> and PGE<jats:sub>2<\/jats:sub> were higher in <jats:italic>pcy<\/jats:italic> compared to normal kidneys. Overall, total COX products were elevated at 30 and 60 days. In contrast, the levels of the lipoxygenase (LOX) products were not altered until 60 days of age and these were lower in <jats:italic>pcy<\/jats:italic> kidneys compared to normal. These findings suggest that altered eicosanoids play a role in NPHP, and that manipulating these levels with pharmacologic agents may have therapeutic potential.<\/jats:p>","DOI":"10.1007\/s11745-013-3859-2","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T03:45:49Z","timestamp":1383191149000},"page":"39-47","source":"Crossref","is-referenced-by-count":13,"title":["Renal Cyclooxygenase Products are Higher and Lipoxygenase Products are Lower in Early Disease in the <i>pcy<\/i> Mouse Model of Adolescent Nephronophthisis"],"prefix":"10.1002","volume":"49","author":[{"given":"Tamio","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Human Nutritional Sciences University of Manitoba W573 Duff Roblin Building Winnipeg MB R3T 2N2 Canada"},{"name":"Canadian Centre for Agri\u2010Food Research in Health and Medicine Winnipeg MB R2H 2A6 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