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Eighteen patients with T2DM, 18 with MetS and 14 controls, paired for age (40\u201370 years) and body mass index (BMI), were studied. Plasma lipids and the kinetics of a triacylglycerol\u2010rich emulsion labeled with [<jats:sup>3<\/jats:sup>H]\u2010triolein ([<jats:sup>3<\/jats:sup>H]\u2010TAG) and [<jats:sup>14<\/jats:sup>C]\u2010cholesteryl esters ([<jats:sup>14<\/jats:sup>C]\u2010CE) injected intravenously followed by one\u2010hour blood sampling were determined. Lipid transfers from an artificial nanoemulsion donor to high\u2010density lipoprotien (HDL) were assayed in vitro. Low\u2010density lipoprotein (LDL) and HDL cholesterol (mg\/dl) were not different in T2DM (128 \u00b1 7; 42 \u00b1 7) and MetS (142 \u00b1 6; 39 \u00b1 3), but triacylglycerols were even higher in MetS (215 \u00b1 13) than in T2DM (161 \u00b111, <jats:italic>p<\/jats:italic> &lt; 0.05). Fractional clearance rate (FCR, in min<jats:sup>1<\/jats:sup>) of [<jats:sup>3<\/jats:sup>H]\u2010TAG and [<jats:sup>14<\/jats:sup>C]\u2010CE were equal in T2DM (0.008 \u00b1 0.018; 0.005 \u00b1 0.024) and MetS (0.010 \u00b1 0.016; 0.006 \u00b1 0.013), and both were reduced compared to controls. The transfer of non\u2010esterified cholesterol, phospholipids and triacylglycerols to HDL was higher in MetS and T2DM than in controls (<jats:italic>p<\/jats:italic> &lt; 0.01). Cholesteryl ester transfer and HDL size were equal in all groups. Results imply that MetS is equal to poorly controlled T2DM concerning the disturbances of plasma lipid metabolism examined here, and suggest that there are different thresholds for the insulin action on glucose and lipids. These findings highlight the magnitude of the lipid disturbances in MetS, and may have implications in the prevention of cardiovascular diseases.<\/jats:p>","DOI":"10.1007\/s11745-014-3899-2","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T08:28:34Z","timestamp":1397032114000},"page":"677-684","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Lipids, Lipoprotein Metabolism and HDL Lipid Transfers are Equally Altered in Metabolic Syndrome and in Type 2 Diabetes"],"prefix":"10.1002","volume":"49","author":[{"given":"Vanessa M.","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (INCOR) do Hospital das Cl\u00ednicas FMUSP Laborat\u00f3rio de Metabolismo de L\u00edpides Av. Dr. En\u00e9as de Carvalho Aguiar, 44, 1\u00b0 Subsolo S\u00e3o Paulo SP 05403\u2010000 Brazil"},{"name":"Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen G. C.","family":"Vinagre","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o (INCOR) do Hospital das Cl\u00ednicas FMUSP Laborat\u00f3rio de Metabolismo de L\u00edpides Av. Dr. En\u00e9as de Carvalho Aguiar, 44, 1\u00b0 Subsolo S\u00e3o Paulo SP 05403\u2010000 Brazil"},{"name":"Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A. 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