{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:08:36Z","timestamp":1793876916246,"version":"4.7.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81001244"],"award-info":[{"award-number":["81001244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lipid metabolism, inflammation, oxidative stress and endothelial function play important roles in the pathogenesis of cardiovascular disease (CVD), which may be affected by an imbalance in the n\u20106\/n\u20103 polyunsaturated fatty acid (PUFA) ratio. This study aimed to investigate the effects of the n\u20106\/n\u20103 PUFA ratio on these cardiovascular risk factors in rats fed a high\u2010fat diet using plant oils as the main n\u20103 PUFA source. The 1:1 and 5:1 ratio groups had significantly decreased serum levels of total cholesterol, low\u2010density lipoprotein cholesterol, and proinflammatory cytokines compared with the 20:1 group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Additionally, the 20:1 group had significantly increased serum levels of E\u2010Selectin, von Willebrand factor (vWF), and numerous markers of oxidative stress compared with the other groups (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The 1:1 group had a significantly decreased lipid peroxide level compared with the other groups (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Serum levels of malondialdehyde, reactive oxygen species and vWF tended to increase with n\u20106\/n\u20103 PUFA ratios increasing from 5:1 to 20:1. We demonstrated that low n\u20106\/n\u20103 PUFA ratio (1:1 and 5:1) had a beneficial effect on cardiovascular risk factors by enhancing favorable lipid profiles, having anti\u2010inflammatory and anti\u2010oxidative stress effects, and improving endothelial function. A high n\u20106\/n\u20103 PUFA ratio (20:1) had adverse effects. Our results indicated that low n\u20106\/n\u20103 PUFA ratios exerted beneficial cardiovascular effects, suggesting that plant oils could be used as a source of n\u20103 fatty acids to prevent CVD. They also suggested that we should be aware of possible adverse effects from excessive n\u20103 PUFA.\n                  <\/jats:p>","DOI":"10.1007\/s11745-015-4091-z","type":"journal-article","created":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T23:11:34Z","timestamp":1446419494000},"page":"49-59","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Low n\u20106\/n\u20103 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stress and Endothelial Function in Rats Using Plant Oils as n\u20103 Fatty Acid Source"],"prefix":"10.1002","volume":"51","author":[{"given":"Li Gang","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health Southeast University 87 Ding Jia Qiao Road Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Xiu","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health Southeast University 87 Ding Jia Qiao Road Nanjing 210009 China"},{"name":"Second Clinical Medical College Nanjing University of Traditional Chinese Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health Southeast University 87 Ding Jia Qiao Road Nanjing 210009 China"},{"name":"School of Food Science and Technology Yangzhou University Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health Southeast University 87 Ding Jia Qiao Road Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Fang","family":"Shu","sequence":"additional","affiliation":[{"name":"Zhongda Hospital Affiliated Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Xia","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhongda Hospital Affiliated Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health Southeast University 87 Ding 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