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Dietary soy protein and fish oil reduce kidney disease progression in the Han:SPRD\u2010<jats:italic>Cy<\/jats:italic> model of cystic renal disease. However, the effects of these dietary interventions in preventing alterations in cardiac structure and function due to kidney disease (reno\u2010cardiac syndrome) in a cystic kidney disease model are not known. Therefore, weanling Han:SPRD\u2010<jats:italic>Cy<\/jats:italic> diseased (<jats:italic>Cy\/<\/jats:italic>+) and normal (+<jats:italic>\/<\/jats:italic>+) rats were given diets containing either casein or soy protein, and either soy or fish oil in a three\u2010way design for 8 weeks. Diseased rats had larger hearts, augmented left ventricular mass, and higher systolic and mean arterial blood pressure compared to the normal rats. Assessment of cardiac function using two\u2010dimensional guided M\u2010mode and pulse\u2010wave Doppler echocardiography revealed that isovolumic relaxation time was prolonged in the diseased compared to normal rats, reflecting a diastolic heart dysfunction, and fish oil prevented this elevation. Soy protein resulted in a small improvement in systolic and mean arterial pressure but did not improve diastolic heart function, while fish oil prevented diastolic heart dysfunction in this model of cystic kidney disease.<\/jats:p>","DOI":"10.1007\/s11745-015-4095-8","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T01:13:51Z","timestamp":1448932431000},"page":"635-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Soy Protein Alleviates Hypertension and Fish Oil Improves Diastolic Heart Function in the Han:SPRD\u2010<i>Cy<\/i> Rat Model of Cystic Kidney Disease"],"prefix":"10.1002","volume":"51","author":[{"given":"Naser H. 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