{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:46:01Z","timestamp":1791830761233,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministry of Science and Higher Education of the Republic of Poland","award":["KNOW 2012-2017"],"award-info":[{"award-number":["KNOW 2012-2017"]}]},{"name":"Medical University of Gdansk","award":["ST-40, ST-89"],"award-info":[{"award-number":["ST-40, ST-89"]}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre of Poland","doi-asserted-by":"crossref","award":["NCN 2013\/11\/B\/N25\/00118"],"award-info":[{"award-number":["NCN 2013\/11\/B\/N25\/00118"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently reported the presence of various cyclopropane fatty acids\u2014among them, cyclopropaneoctanoic acid 2\u2010hexyl\u2014in the adipose tissue of obese women. The aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2\u2010hexyl in human serum was associated with obesity or chronic kidney disease (both being related to dyslipidemia), and to find potential associations between the serum level of this compound and specific markers of the these conditions. The serum concentration of cyclopropaneoctanoic acid 2\u2010hexyl was determined by gas chromatography\u2013mass spectrometry (GC\u2013MS) in non\u2010obese controls, obese patients, obese patients after a 3\u2010month low\u2010calorie diet, and individuals with chronic kidney disease. Obese patients and those with chronic kidney disease presented with higher serum levels of cyclopropaneoctanoic acid 2\u2010hexyl than controls. Switching obese individuals to a low\u2010calorie (low\u2010lipid) diet resulted in a reduction in this fatty acid concentration to the level observed in controls. Cyclopropaneoctanoic acid 2\u2010hexyl was also found in foods derived from animal fat. Serum concentrations of triacylglycerols in the analyzed groups followed a pattern similar to that for serum cyclopropaneoctanoic acid 2\u2010hexyl, and these variables were positively correlated with each other among the studied groups. Patients with hypertriglyceridemia\u2010related conditions presented with elevated serum levels of cyclopropaneoctanoic acid 2\u2010hexyl. Our findings suggest that its high serum level is related to high serum triacylglycerol concentrations rather than to body mass or BMI.<\/jats:p>","DOI":"10.1007\/s11745-016-4141-1","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T04:01:09Z","timestamp":1458619269000},"page":"867-873","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Increased Serum Level of Cyclopropaneoctanoic Acid 2\u2010Hexyl in Patients with Hypertriglyceridemia\u2010Related Disorders"],"prefix":"10.1002","volume":"51","author":[{"given":"Adriana","family":"Mika","sequence":"first","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry University of Gdansk 63 Wita Stwosza Str. Gdansk 80\u2010308 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Stepnowski","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry University of Gdansk 63 Wita Stwosza Str. Gdansk 80\u2010308 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Chmielewski","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Medicine Medical University of Gdansk 7 Debinki Str. Gdansk 80\u2010952 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Malgorzewicz","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Medical University of Gdansk 7 Debinki Str. Gdansk 80\u2010952 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Kaska","sequence":"additional","affiliation":[{"name":"Department of General, Endocrine and Transplant Surgery Medical University of Gdansk 17 Smoluchowskiego Str. Gdansk 80\u2010214 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Proczko","sequence":"additional","affiliation":[{"name":"Department of General, Endocrine and Transplant Surgery Medical University of Gdansk 17 Smoluchowskiego Str. Gdansk 80\u2010214 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Ratnicki\u2010Sklucki","sequence":"additional","affiliation":[{"name":"Department of General, Endocrine and Transplant Surgery Medical University of Gdansk 17 Smoluchowskiego Str. Gdansk 80\u2010214 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Sledzinski","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Medical University of Gdansk 17 Smoluchowskiego Str. Gdansk 80\u2010214 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Sledzinski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry Medical University of Gdansk 1 D\u0119binki Str. Gdansk 80\u2010211 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/.61.4.429-441.1997"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00403a029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2229-11-97"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.113.230953"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-007-3047-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16129972"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(99)00016-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-013-3806-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.231969"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3181"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500329-JLR200"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-013-3823-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.01.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092152999"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-4753(03)80028-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121320"},{"key":"e_1_2_9_18_1","first-page":"418","article-title":"Fatty acids regulation of inflammatory and metabolic genes","volume":"16","author":"Masi LN","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.040"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-120"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4057204"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11745-016-4141-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11745-016-4141-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-016-4141-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:24:32Z","timestamp":1760963072000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-016-4141-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,22]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1007\/s11745-016-4141-1"],"URL":"https:\/\/doi.org\/10.1007\/s11745-016-4141-1","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,22]]}}}