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We reported on the heretofore unknown therapeutic effect of Danshensu (DSS) in reducing intracellular cholesterol level and unraveled the mechanism of DSS promotes cholesterol efflux. Oxidized low\u2010density lipoprotein stimulation of Raw264.7 cells into foam cells, which were treated with DSS and co\u2010treated with Simvastatin and Rosiglitazone. PPAR\u03b3, ABCA1, ABCG1, SR\u2010BI, CD36, and LXR\u2010\u03b1 mRNA were quantified by Real\u2010Time PCR. Western blotting was used to determine protein expression of PPAR\u03b3, ABCA1 and CD36. Cellular cholesterol handling was studied by measurement of intracellular lipid droplets concentration and cholesterol efflux. DSS significantly reduced scavenger receptor CD36 and its orthologue SR\u2010BI. In addition, DSS stimulated the upregulation of cellular cholesterol exporters ABCA1 and ABCG1 to reduce intracellular lipid accumulation. DSS can reduce lipid deposition in Raw264.7 foam cells by balancing CD36 and ABCA1 protein expression.<\/jats:p>","DOI":"10.1007\/s11745-016-4178-1","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T03:55:37Z","timestamp":1470887737000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Danshensu Promotes Cholesterol Efflux in RAW264.7 Macrophages"],"prefix":"10.1002","volume":"51","author":[{"given":"Hui","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin 300193 China"},{"name":"Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Tianjin University of Traditional Chinese Medicine #312 Anshanxi Road, Nankai District Tianjin 300193 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