{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:26:13Z","timestamp":1791005173843,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lipid emulsions influence platelet aggregation and receptor expression. However, the effect on platelet function is not fully explained. Therefore, the aim of this study was to examine the influence of the lipids Lipofundin<jats:sup>\u00ae<\/jats:sup>, Lipidem<jats:sup>\u00ae<\/jats:sup> and ClinOleic<jats:sup>\u00ae<\/jats:sup> on surface expressions of P\u2010selectin, GPIb and GPIIb\/IIIa on platelets <jats:italic>in vitro<\/jats:italic>. Whole blood was incubated in two different concentrations (0.06 and 0.6 mg\/ml) of LCT\/MCT, n\u20103\/LCT\/MCT and LCT\u2010MUFA for 30 min, followed by activation with TRAP\u20106 or ADP for flow\u2010cytometric assay. Rates of P\u2010selectin, GPIb and GPIIb\/IIIa expression were analyzed. There was a significant increase in GPIIb\/IIIa\u2010 and P\u2010selectin\u2010expression after incubation with LCT\/MCT and n\u20103\/LCT\/MCT at the concentration of 0.6 mg\/ml, without and after stimulation with TRAP\u20106 and ADP. GPIb was significantly decreased. Accordingly, LCT\u2010MUFA had no effect on receptor expression of platelets <jats:italic>in vitro<\/jats:italic>. We demonstrated that LCT\u2010MUFA did not activate receptor expression of platelets whereas LCT\/MCT significantly increased platelet aggregation <jats:italic>in vitro<\/jats:italic>. This finding should be noted for parenteral nutrition of intensive care patients and, in the future, might provide further insight into the pathogenic pathways of acute thromboembolic events. However, prospectively designed clinical studies are needed to support our results.<\/jats:p>","DOI":"10.1007\/s11745-016-4182-5","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T07:52:11Z","timestamp":1470988331000},"page":"1241-1248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Olive Oil\u2010Based Lipid Emulsions Do Not Influence Platelet Receptor Expression in Comparison to Medium and Long Chain Triglycerides <i>In vitro<\/i>"],"prefix":"10.1002","volume":"51","author":[{"given":"Carsten","family":"Stoetzer","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Hannover Medical School Carl\u2010Neuberg Strasse 1 Hannover 30625 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorben","family":"Doll","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Hannover Medical School Carl\u2010Neuberg Strasse 1 Hannover 30625 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"J\u00fcttner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Hannover Medical School Carl\u2010Neuberg Strasse 1 Hannover 30625 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