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However, its influence on the inflammatory response and metabolic changes in white adipose tissue remains unknown. We used male C57BL\/6 mice as models to study the effect of \u03b1\u2010LA on the inflammatory response and metabolic changes in white adipose tissue after stimulation with lipopolysaccharide (LPS). The non\u2010esterified fatty acid content was measured by an automatic biochemical analyzer. The expression of inflammation\u2010, lipid\u2010 and energy metabolism\u2010related genes and proteins was determined by quantitative real\u2010time polymerase chain reaction and western blotting. The results indicated that \u03b1\u2010LA significantly decreased the epididymis fat weight index and the non\u2010esterified fatty acid content in plasma compared with the control group. LPS significantly increased the expression of inflammation genes and \u03b1\u2010LA reduced their expression. The LPS\u2010induced expression of nuclear factor\u2010\u03baB protein was decreased by \u03b1\u2010LA. Regarding lipid metabolism, \u03b1\u2010LA significantly counteracted the inhibitory effects of LPS on the expression of hormone\u2010sensitive lipase gene and protein. \u03b1\u2010LA evidently increased the gene expression of fatty acid transport protein 1 and cluster of differentiation 36. Regarding energy metabolism, \u03b1\u2010LA significantly increased the expression of most of mitochondrial DNA\u2010encoded genes compared with the control and LPS group. Accordingly, \u03b1\u2010LA can alleviate acute inflammatory response and this action may be related with the promotion of lipid mobilization in white adipose tissue.<\/jats:p>","DOI":"10.1007\/s11745-016-4185-2","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:13:13Z","timestamp":1471306393000},"page":"1145-1152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Alpha\u2010Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice"],"prefix":"10.1002","volume":"51","author":[{"given":"Jun","family":"Guo","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Physiology and Biochemistry Nanjing Agricultural University Nanjing 210095 People's Republic of 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Agricultural University Nanjing 210095 People's Republic of 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