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We have previously shown that IUGR male rats demonstrated increased <jats:italic>de novo<\/jats:italic> fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, <jats:italic>de novo<\/jats:italic> synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid <jats:italic>de novo<\/jats:italic> synthesis in IUGR adult males (6 months) using deuterium\u2010enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline <jats:italic>de novo<\/jats:italic> synthesis in both SC fat and visceral fat. Correspondingly, SC and visceral fat protein expression of lipogenic enzymes acetyl\u2010coA carboxylase\u2010\u03b1 (ACC\u03b1) and fatty acid synthase were upregulated. After the isocaloric high fat diet, <jats:italic>de novo<\/jats:italic> synthesis was suppressed such that no differences remained between the two groups, although, IUGR SC fat demonstrated persistently increased lipogenic protein expression. In contrast, <jats:italic>de novo<\/jats:italic> synthesis among adult females is not impacted in IUGR. In conclusion, enhancement of male IUGR SC fat <jats:italic>de novo<\/jats:italic> synthesis appears to be an early consequence of metabolic programming, whereas enhancement in visceral fat appears to be a later consequence.<\/jats:p>","DOI":"10.1007\/s11745-016-4199-9","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T08:34:41Z","timestamp":1474533281000},"page":"1339-1351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fatty Acid <i>de Novo<\/i> Synthesis in Adult Intrauterine Growth\u2010Restricted Offspring, and Adult Male Response to a High Fat Diet"],"prefix":"10.1002","volume":"51","author":[{"given":"Jennifer K.","family":"Yee","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics Los Angeles Biomedical Research Institute at Harbor\u2010UCLA 1124 West Carson Street Torrance CA 90502 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