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This study was carried out in order to examine the effect of conjugated linoleic acid (CLA) on bone markers in rheumatoid arthritis disease which is the most common autoimmune disease. The present study is a randomized double\u2010blind clinical trial. Subjects included 52 patients with active rheumatoid arthritis who were divided into two groups. Group I received standard treatment plus 2 daily 1.25 g capsules (Containing about 2 g of 9\u2010<jats:italic>cis<\/jats:italic> 11\u2010<jats:italic>trans<\/jats:italic> isomer and 10\u2010<jats:italic>cis<\/jats:italic> 12\u2010<jats:italic>trans<\/jats:italic> isomer in ratio of 50 \u221250 CLA in glycerinated form), Group II received standard treatment plus 2 Placebo 1.25 g capsules containing sunflower oil with high oleic acid. Telopeptides C, osteocalcin, and MMP3 were analyzed by ELISA method, PGE<jats:sub>2<\/jats:sub> was done by competitive enzymatic immunoassay method, and IGF\u20101 was analyzed by the IRMA method based on the sandwich method and ALK\u2010P of bone. Before and after the intervention, the questionnaires about general information, nutrition assessment and medical history were filled out by the subjects. Nutritional assessment was done by a 24\u2010h record questionnaire for the three\u2010day diet. The results were analyzed using SPSS software (version 18). Findings: There was no significant difference between the groups in enzyme activity of ALK\u2010P of bone, PGE<jats:sub>2<\/jats:sub> and MMP3 variables. However, differences between the two groups in terms of activity of telopeptides C, Osteocalcin, and IGF1 were significant (<jats:italic>P<\/jats:italic> &lt; 0.05). CLA has a potentially beneficial effect on bone markers in patients with rheumatoid arthritis. Therefore, in order to study the effect of CLA on bone health in patients with RA and all patients with autoimmune and bone diseases more studies with longer duration and evaluation of bone mass density are required.<\/jats:p>","DOI":"10.1007\/s11745-016-4201-6","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T02:13:06Z","timestamp":1478225586000},"page":"1397-1405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["CLA Has a Useful Effect on Bone Markers in Patients with Rheumatoid Arthritis"],"prefix":"10.1002","volume":"51","author":[{"given":"N.","family":"Aryaeian","sequence":"first","affiliation":[{"name":"Research Center for Environmental Health Technology, Iran University of Medical Sciences and Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Shahram","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Djalali","sequence":"additional","affiliation":[{"name":"Departments of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","first-page":"S18","article-title":"The assessment of disease activity in rheumatoid arthritis","volume":"28","author":"Smolen JS","year":"2010","journal-title":"Clin Exp 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