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In metabolic syndrome, an insulin resistant state along with high plasma levels of free fatty acids (FFA) and hyperglycemia may contribute to the lipogenic process. The aim of the present study was to investigate the effects of oral administration of metformin on the expression of lipogenic genes and glycemic profile in mice fed with low\u2010carbohydrate high\u2010fat diet by evaluating their metabolic profile. SWISS male mice were divided into 4 groups (<jats:italic>N<\/jats:italic> = 7) that were fed with standard (ST), standard plus metformin (ST + MET), low\u2010carbohydrate high\u2010fat diet (LCHFD) and low\u2010carbohydrate high\u2010fat diet plus metformin (LCHFD + MET) (100 mg kg<jats:sup>\u22121<\/jats:sup> diet) diets respectively. Food intake, body weight and blood parameters, such as glucose tolerance, insulin sensitivity, glucose, HDL\u2010c, total cholesterol, triglycerides, ASL and ALT levels were assessed. Histological analyses were performed on hematoxylin and eosin\u2010stained epididymal adipose tissue histological specimens. The expression levels of peroxisome proliferator\u2010activated receptor (PPAR\u03b3), sterol regulatory element\u2010binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl\u2010CoA carboxylase (ACC), were assessed by RT\u2010PCR. This study showed that metformin decreased adipocyte area, body weight and food consumption in obese animals when compared to the standard group. Furthermore, the expression of lipogenic markers in adipose tissue were diminished in obese animals treated with metformin. This data showed that oral administration of metformin improved glucose and lipid metabolic parameters in white adipose tissue by reducing the expression of lipogenesis markers, suggesting an important clinical application of MET in treating obesity\u2010related diseases in metabolic syndrome.<\/jats:p>","DOI":"10.1007\/s11745-016-4209-y","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T10:16:00Z","timestamp":1477995360000},"page":"1375-1384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metformin Reduces Lipogenesis Markers in Obese Mice Fed a Low\u2010Carbohydrate and High\u2010Fat Diet"],"prefix":"10.1002","volume":"51","author":[{"given":"Karla Nayara","family":"de Oliveira Santana","sequence":"first","affiliation":[{"name":"Laboratory of Health Science, Postgraduate Program in Health Sciences Universidade Estadual de Montes Claros (Unimontes) Montes Claros MG 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