{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:05:11Z","timestamp":1785769511748,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is associated with metabolic syndrome and cardiovascular disease. Fatty acid\u2010binding proteins (FABP) have been recognized as predictors of these systemic disorders. The aim of this study was to assess correlations between levels of serum heart and adipocyte fatty acid\u2010binding proteins (FABP3, FABP4) and disease severity, indicators of inflammation or metabolic disturbances, and topical treatment in psoriatic patients. Thirty\u2010seven patients with relapse of plaque\u2010type psoriasis and 16 healthy volunteers were recruited. Blood samples were collected before and after 14 days of therapy. Serum FABP concentrations were examined by enzyme\u2010linked immunosorbent assay for correlation with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory or metabolic parameters, and treatment used. The median FABP4 serum levels were significantly increased (<jats:italic>p<\/jats:italic> = 0.038) in psoriatic patients, while FABP3 levels did not differ (<jats:italic>p<\/jats:italic> = 0.47) compared to the controls. No significant correlations were noted between the proteins and PASI, C\u2010reactive protein (CRP), BMI, or levels of glucose or lipids. FABP3 significantly correlated with white blood count (<jats:italic>p<\/jats:italic> = 0.03) and aspartate aminotransferase (<jats:italic>p<\/jats:italic> = 0.04). After topical treatment, there was no significant change in serum FABP3 [11.5 (4.9\u201330.3) vs. 12.9 (3.5\u201330.3) ng\/ml] (<jats:italic>p<\/jats:italic> = 0.96), whereas FABP4 was decreased [27,286 (20,344\u201332,257) vs. 23,034 (18,320\u201329,874) pg\/ml] (<jats:italic>p<\/jats:italic> = 0.12), losing its basal significance. FABP4 may be a marker of psoriasis, and FABP3 may be associated with inflammation or liver disorders in psoriatic patients. FABP do not appear to be useful for determining disease severity or the effectiveness of antipsoriatic treatment.<\/jats:p>","DOI":"10.1007\/s11745-016-4211-4","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T01:20:24Z","timestamp":1479432024000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Serum Fatty Acid\u2010Binding Protein 4 is Increased in Patients with Psoriasis"],"prefix":"10.1002","volume":"52","author":[{"given":"A.","family":"Baran","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Zurawia 14 St Bialystok 15\u2010540 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"\u015awiderska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Zurawia 14 St Bialystok 15\u2010540 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Bacharewicz\u2010Szczerbicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Zurawia 14 St Bialystok 15\u2010540 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"My\u015bliwiec","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Zurawia 14 St Bialystok 15\u2010540 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Zurawia 14 St Bialystok 15\u2010540 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NPR.0000453651.30695.43"},{"key":"e_1_2_9_3_1","first-page":"28","article-title":"Cardiovascular risk factors in patients with chronic plaque psoriasis: a case\u2010control study on the Brasov County population","volume":"23","author":"Irimie M","year":"2015","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018125"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2015.69.85-87"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"9","article-title":"Psoriasis: comorbidities and associations","volume":"146","author":"Farley E","year":"2011","journal-title":"G Ital Dermatol Veneorol"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"23","article-title":"Fatty acid\u2010binding protein 4 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