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Some health benefits of n\u20103 PUFA are mediated through the impact of their oxygenated metabolites, i.e. oxylipins. The TFA, <jats:italic>trans<\/jats:italic>\u201010, <jats:italic>cis<\/jats:italic>\u201012\u2010conjugated linoleic acid (CLA; 18:2n\u20106) is associated with adipose tissue (AT) inflammation, oxidative stress, and wasting. We examined the impact of a 4\u2010week feeding of 0, 0.5, and 1.5% docosahexaenoic acid (DHA; 22:6n\u20103) in the presence and absence of 0.5% CLA on AT oxylipin profiles in female C57BL\/6N mice. Esterified oxylipins in AT derived from linoleic acid (LNA), alpha\u2010linolenic acid (ALA), arachidonic acid (ARA), eicosapentaenoic acid (EPA), DHA, and putative from CLA were quantified. CLA containing diets reduced AT mass by ~62%. Compared with the control diet, the DHA diet elevated concentrations of EPA\u2010and DHA\u2010derived alcohols and epoxides and LNA\u2010derived alcohols, reduced ARA\u2010derived alcohols, ketones, epoxides, and 6\u2010keto\u2010prostaglandin (PG) F<jats:sub>1\u03b1<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.05), and had mixed effects on ALA\u2010derived alcohols. Dietary CLA lowered EPA\u2010, DHA\u2010, and ALA\u2010derived epoxides, ARA\u2010derived ketones and epoxides, and ALA\u2010derived alcohols. While dietary CLA induced variable effects in EPA\u2010, DHA\u2010, and LNA\u2010derived alcohols and LNA\u2010derived ketones, it elevated ARA\u2010derived alcohols and PGF<jats:sub>1\u03b1<\/jats:sub>, PGF<jats:sub>2\u03b1<\/jats:sub>, and F2\u2010isoprostanes. DHA counteracted CLA\u2010induced effects in 67, 57, 43, and 29% of total DHA\u2010, ARA\u2010, EPA\u2010, and ALA\u2010derived oxylipins, respectively. Thus, CLA elevated proinflammatory oxylipins while DHA increased anti\u2010inflammatory oxylipins and diminished concentration of CLA\u2010induced pro\u2010inflammatory oxylipins in AT.<\/jats:p>","DOI":"10.1007\/s11745-017-4252-3","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:59:56Z","timestamp":1492084796000},"page":"399-413","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dietary Docosahexaenoic Acid and <i>trans<\/i>\u201010, <i>cis<\/i>\u201012\u2010Conjugated Linoleic Acid Differentially Alter Oxylipin Profiles in Mouse Periuterine Adipose Tissue"],"prefix":"10.1002","volume":"52","author":[{"given":"Yuriko","family":"Adkins","sequence":"first","affiliation":[{"name":"Western Human Nutrition Research Center, Agricultural Research Service United States Department of Agriculture 430 West Health Sciences Drive Davis CA 95616 USA"},{"name":"Department of 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University of California Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Western Regional Research Center, Agricultural Research Service United States Department of Agriculture Albany CA 94710 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Newman","sequence":"additional","affiliation":[{"name":"Western Human Nutrition Research Center, Agricultural Research Service United States Department of Agriculture 430 West Health Sciences Drive Davis CA 95616 USA"},{"name":"Department of Nutrition University of California Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darshan S.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Western Human Nutrition Research Center, Agricultural Research Service United States Department of Agriculture 430 West Health Sciences Drive Davis CA 95616 USA"},{"name":"Department of Nutrition University of California Davis CA 95616 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