{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:49:45Z","timestamp":1790707785128,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:00:00Z","timestamp":1495843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:00:00Z","timestamp":1495843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ethanolamine plasmalogen (PlsEtn), a major phospholipid in neuronal membranes [60\u201390 mol% of ethanolamine glycerophospholipid (EtnGpl)], is specifically decreased in brains from patients with Alzheimer's disease (AD). The present study investigated how PlsEtn administration affects cognitive deficits and lipid composition in an animal model of AD. AD model rats were infused with amyloid\u2010\u03b2 (A\u03b2) into the cerebral ventricle and divided into three groups. Control, Egg, and Ascidian groups were then orally administered vehicle, egg yolk EtnGpl (260 \u03bcmol as EtnGpl\/kg BW\/day; 10 \u03bcmol as PlsEtn\/kg BW\/day), or ascidian viscera EtnGpl (260 \u03bcmol as EtnGpl\/kg BW\/day; 209 \u03bcmol as PlsEtn\/kg BW\/day), respectively. After 4 weeks of dosing, A\u03b2\u2010infused rats were tested for learning ability in an 8\u2010arm radial maze. The administration of ascidian viscera EtnGpl improved both reference and working memory\u2010related learning abilities. In lipid analysis, the Ascidian group showed higher levels of PlsEtn species in the plasma, erythrocytes, and liver when compared to other groups. In addition, although there were no differences at levels of total plasmalogen including choline plasmalogen, the Ascidian group had significantly higher levels of 18:0ol\/22:6\u2010PlsEtn in the cerebral cortex. These levels of 18:0ol\/22:6\u2010PlsEtn in the cerebral cortex were correlated with working memory\u2010related learning ability. Moreover, 18:0ol\/22:6\u2010PlsEtn levels in the cerebral cortex showed positive correlations with those in the erythrocytes and liver. In summary, dietary PlsEtn, especially that with 22:6n\u20103 (docosahexaenoic acid, DHA), may ameliorate learning deficiencies in AD by altering lipid composition in the brain.<\/jats:p>","DOI":"10.1007\/s11745-017-4260-3","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T02:23:00Z","timestamp":1495851780000},"page":"575-585","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Oral Administration of Ethanolamine Glycerophospholipid Containing a High Level of Plasmalogen Improves Memory Impairment in Amyloid \u03b2\u2010Infused Rats"],"prefix":"10.1002","volume":"52","author":[{"given":"Shinji","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Food Science Obihiro University of Agriculture and Veterinary Medicine Obihiro 080\u20108555 Japan"},{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science Tohoku 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