{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:31:36Z","timestamp":1790109096256,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to obtain functional information associated with the prevention by n\u22123 polyunsaturated fatty acids (PUFA) of ischemia\u2010induced fatal cardiac ventricular arrhythmias in the intact, conscious, exercising dog. Thirteen dogs suceptible to ischemia\u2010induced ventricular fibrillation were prepared surgically by ligation of their anterior descending left coronary artery and placement of an inflatable cuff around their left circumflex artery. After 4 wk of recovery, exercise\u2010plus\u2010ischemia tests were performed without and then with an intravenous infusion of an emulsion of free n\u22123 PUFA just prior to occluding the left circumflex artery while the animals were running on a treadmill. One week later the exercise\u2010plus\u2010ischemia test was repeated but with a control infusion replacing the emulsion of n\u22123 PUFA. The infusion of the free n\u22123 PUFA in quantities of 1.0 to 10 g prevented ventricular fibrillation in 10 of the 13 dogs tested (<jats:italic>P<\/jats:italic>&lt;0.005), apparently without esterification of the PUFA into membrane phospholipids. The antiarrhythmic effect of the n\u22123 PUFA was associated with slowing of the heart rate, shortening of the QT\u2010interval (electrical action potential duration), reduction of left ventricular systolic pressure, and prolongation of the electrocardiographic atrial\u2010ventricular conduction time (P\u2010R interval). These effects are comparable with those we have reported in studies with cultured neonatal rat cardiac myocytes.<\/jats:p>","DOI":"10.1007\/s11745-997-0149-2","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T13:03:16Z","timestamp":1163422996000},"page":"1161-1168","source":"Crossref","is-referenced-by-count":146,"title":["Prevention of ischemia\u2010induced cardiac Sudden death by n\u22123 polyunsaturated fatty acids in dogs"],"prefix":"10.1002","volume":"32","author":[{"given":"George E.","family":"Billman","sequence":"first","affiliation":[{"name":"Department of Physiology The Ohio State University Columbus Ohio 45210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing X.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital Boston Massachusetts 02114"},{"name":"Harvard Medical School Boston Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Leaf","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital Boston Massachusetts 02114"},{"name":"Harvard Medical School Boston Massachusetts 02115"},{"name":"Massachusetts General Hospital East, Bldg. 149, 13th St. Charlestown MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,11]]},"reference":[{"key":"e_1_2_2_2_1","volume-title":"Heart and Stroke Facts: Statistical Supplement","author":"American Heart Association","year":"1995"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","unstructured":"Gudbjarnason S. andHallgrimsson J.(1975)The Role of Myocardial Membrane Lipids in the Development of Cardiac Necrosis Acta Med. 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