{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:07Z","timestamp":1761007447342,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some tetracycline (TC) antibiotics, including TC and anhydrotetracycline, have been found to enhance specific binding of low density lipoprotein (LDL) to both LDL receptor\u2010positive and\u2010negative cells at relatively higher concentrations. When incubated at 37\u00b0C, the ability of LDL receptor\u2010negative human fibroblasts to bind <jats:sup>125<\/jats:sup>I\u2010LDL was increased from&lt;2 to 45 ng\/mg by 170 \u03bcM TC. In normal human fibroblasts and Hep G2 cells, <jats:sup>125<\/jats:sup>I\u2010LDL binding was elevated 1.4\u2010 to 2\u2010fold by 113 \u03bcM TC. The <jats:sup>125<\/jats:sup>I\u2010LDL binding in the presence of TC was diminished by both heparin and EDTA. The enhancement by TC was not observed when <jats:sup>125<\/jats:sup>I\u2010LDL binding was assayed at 4\u00b0C. TC enhanced LDL binding to paraformaldehyde\u2010fixed Hep G2 cells, excluding LDL receptor induction in the mechanism. These results demonstrated that TC enhanced cellular LDL binding through a process not involving functional LDL receptors.<\/jats:p>","DOI":"10.1007\/s11745-998-0177-y","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T13:18:02Z","timestamp":1163423882000},"page":"33-38","source":"Crossref","is-referenced-by-count":0,"title":["Enhancement of low density lipoprotein binding to both low density lipoprotein receptor\u2010positive and\u2010 negative cells by tetracycline antibiotics"],"prefix":"10.1002","volume":"33","author":[{"given":"Shinji","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University 3\u20105\u20108 Saiwaicho Fucho, Tokyo 183 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hasumi","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University 3\u20105\u20108 Saiwaicho Fucho, Tokyo 183 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Takayasu","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University 3\u20105\u20108 Saiwaicho Fucho, Tokyo 183 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University 3\u20105\u20108 Saiwaicho Fucho, Tokyo 183 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University 3\u20105\u20108 Saiwaicho Fucho, Tokyo 183 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,1]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.4159\/harvard.9780674497887.intro"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-1-1"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.46.070177.004341"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34287-X"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.11.3499"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108273050909"},{"key":"e_1_2_2_9_1","first-page":"103","volume-title":"Treatment of Hyperlipoproteinemia","author":"Goldstein J.L.","year":"1984"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41379-3"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.5151"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a122003"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280546"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(83)98152-1"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb16848.x"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb43358.x"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01498a037"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(92)90322-Z"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.003125"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31921-X"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.518"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600520403"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-998-0177-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:23:44Z","timestamp":1760966624000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-998-0177-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1007\/s11745-998-0177-y"],"URL":"https:\/\/doi.org\/10.1007\/s11745-998-0177-y","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}