{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:59:45Z","timestamp":1767905985096,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Postoperative intrapericardial adhesion increases the risk of complications in patients undergoing reoperation. We investigated the effect of a bioabsorbable dextrin hydrogel (DHG) on the formation of intrapericardial adhesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intrapericardial adhesion was surgically induced in Japanese white rabbits with DHG treatment (Adh\u2009+\u2009DHG) or without DHG treatment (Adh). The sham group was not treated with DHG and intrapericardial adhesion was not induced. The extent of intrapericardial adhesion was assessed by adhesion scoring and crystal violet staining of the pericardial cavity. Bromodeoxyuridine (BrdU) uptake assay was performed to assess the proliferative response to the injury in the tissue beneath the intrapericardial adhesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Adh\u2009+\u2009DHG group showed looser intrapericardial adhesions compared to the Adh group. The adhesion area of the Adh\u2009+\u2009DHG group was 4.6\u2009\u00b1\u20092.2%, whereas that of the Adh group was 32.6\u2009\u00b1\u20096.4% at the end of the 28-day observation period (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The induction of intrapericardial adhesion resulted in a proliferative response mainly in the cardiac tissue just beneath the adhesion. There were 48.6\u2009\u00b1\u200910.7 cells\/0.1\u00a0mm<jats:sup>2<\/jats:sup>BrdU-positive cells in the Adh\u2009+\u2009DHG group and 135.7\u2009\u00b1\u200923.8 cells\/0.1\u00a0mm<jats:sup>2<\/jats:sup>BrdU-positive cells in the Adh group on day 28 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicate that DHG effectively prevented intrapericardial adhesion in this model.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11748-020-01581-2","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T07:15:59Z","timestamp":1610090159000},"page":"1326-1334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevention of postoperative intrapericardial adhesion by dextrin hydrogel"],"prefix":"10.1007","volume":"69","author":[{"given":"Satoshi","family":"Kikusaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Shojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Saku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomofumi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsunobu","family":"Oryoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Anegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9578-3188","authenticated-orcid":false,"given":"Hiroki","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"1581_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.actbio.2018.10.022","volume":"83","author":"B Feng","year":"2019","unstructured":"Feng B, Wang S, Hu D, Fu W, Wu J, Hong H, et al. 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The donation was not used for the current research project, and TERUMO had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. The authors have no other potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocol was approved by the Animal Experiment Committee of the Kurume University School of Medicine in accordance with the Guidelines for Proper Conduct of Animal Experiments by the Science Council of Japan. Animal care and usage were in compliance with the Guide for the Care and Use of Laboratory Animals issued by the Institute of Animal Experimentation of Kurume University School of Medicine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}