{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:28:30Z","timestamp":1791350910434,"version":"4.3.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the National Key R&D Program of China","award":["2018YFC1314000"],"award-info":[{"award-number":["2018YFC1314000"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81603461"],"award-info":[{"award-number":["81603461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Furosemide is usually administered before the Coronary artery bypass grafting (CABG) to improve water\u2013sodium retention. However, no final conclusions are available on the postoperative renal outcome of furosemide. We evaluated the effect of preoperative furosemide on acute kidney injury (AKI) after CABG.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We recorded the use of furosemide 14\u00a0days before surgery in all patients who underwent CABG from 2016 to 2017. Patients were divided into furosemide (F) group and non-furosemide (NF) group according to preoperative use of furosemide. A 1:1 propensity score matching was performed. Multivariate analyses were conducted to determine risk factors for AKI after CABG.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 974 patients were included in the study, of which 82 cases were complicated with postoperative AKI. The incidence of AKI was significantly increased in F group than NF group (28.9% vs. 7.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.000). After adjusting for risk factors, the incidence of AKI in the F group was 5.34 times more than the NF group (95% confidence interval [CI] 2.45\u201311.64; <jats:italic>p<\/jats:italic>\u2009=\u20090.000). The incidence of AKI increased significantly when the cumulative dosage of furosemide exceeded 110\u00a0mg (odds ratio [OR] 6.23; 95% CI 2.07\u201318.74, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and 250\u00a0mg (OR 8.31; 95% CI 2.87\u201324.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.000). After the propensity-matching group analysis, same results were obtained.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The incidence of AKI after CABG was related to the use of preoperative furosemide, and it increased exponentially with the increase of cumulative dose of furosemide. This provides guidance for the dose of preoperative furosemide.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11748-021-01599-0","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T22:50:39Z","timestamp":1612824639000},"page":"1392-1399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preoperative use of furosemide may increase the incidence of acute kidney injury after coronary artery bypass grafting: a propensity score-matched study"],"prefix":"10.1007","volume":"69","author":[{"given":"Hui","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-6644","authenticated-orcid":false,"given":"Baocheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"1599_CR1","unstructured":"Shengshou Hu,Runlin Gao,Lisheng Liu,Manlu Zhu,Wen wang,Yongjun Wang,et al. Summary of China cardiovascular disease report 2018. China circulation magazine, 2019,34(3): 209\u2013220. 2.Garg AX,Devereaux PJ,Yusuf S, Cuerden MS,Parikh CR,Coca SG,et al.Kidney function after off\u2011pump or on\u2011pump coronary artery bypass graft surgery: A randomized clinical trial.JAMA,2014,311:2191\u20112198."},{"key":"1599_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1161\/CIRCHEARTFAILURE.112.971705","volume":"6","author":"D Olsson","year":"2013","unstructured":"Olsson D, Sartipy U, Braunschweig F, Holzmann MJ. Acute kidney injury following coronary artery bypass surgery and long-term risk of heart failure. Circ Heart Fail. 2013;6:83\u201390.","journal-title":"Circ Heart Fail"},{"issue":"4","key":"1599_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/icvts\/ivv184","volume":"21","author":"S Takaki","year":"2015","unstructured":"Takaki S, Shehabi Y, Pickering JW, Endre Z, Miyashita T, Goto T, et al. Perioperative change in creatinine following cardiac surgery with cardiopulmonary bypass is useful in predicting acute kidney injury: a single-centre retrospective cohort study. Interact Cardiovasc Thorac Surg. 2015;21(4):465\u20139.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"4","key":"1599_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.21470\/1678-9741-2017-0251","volume":"33","author":"C Ortega-Loubon","year":"2018","unstructured":"Ortega-Loubon C, Fern\u00e1ndez-Molina M, Pa\u00f1eda-Delgado L, Jorge-Monjas P, Carrascal Y, et al. Predictors of Postoperative Acute Kidney Injury after Coronary Artery Bypass Graft Surgery. Braz J Cardiovasc Surg. 2018;33(4):323\u20139.","journal-title":"Braz J Cardiovasc Surg"},{"key":"1599_CR5","doi-asserted-by":"crossref","unstructured":"Li Z,Fan G, Zheng X, Gong X, Chen T, Liu X,et al. Risk factors and clinical significance of acute kidney injury after on-pump or off-pump coronary artery bypass grafting: a propensity score-matched study.Interact Cardiovasc Thorac Surg.2019;28(6):893\u2013899.","DOI":"10.1093\/icvts\/ivy353"},{"key":"1599_CR6","doi-asserted-by":"publisher","unstructured":"Daci A, Bozalija A, Cavolli R, Alaj R, Beretta G, Krasniqi S,et al.Pharmacotherapy Evaluation and Utilization in Coronary Artery Bypass Grafting Patients in Kosovo during the Period 2016\u20132017.Open Access Maced J Med Sci.2018;12;6(3):498\u2013505. doi: https:\/\/doi.org\/10.3889\/oamjms.2018.132. eCollection 2018 Mar 15.","DOI":"10.3889\/oamjms.2018.132"},{"key":"1599_CR7","doi-asserted-by":"crossref","unstructured":"Gandhi A, Husain M, Salhiyyah K, Raja SG,et al.Does perioperative furosemide usage reduce the need for renal replacement therapy in cardiac surgery patients?Interact Cardiovasc Thorac Surg. 2012,15(4):750\u20135. Epub 2012 Jul 3.","DOI":"10.1093\/icvts\/ivs208"},{"key":"1599_CR8","doi-asserted-by":"crossref","unstructured":"Lombardi R, Ferreiro A, Servetto C. Renal function after cardiac surgery: adverse effect of furosemide.Ren Fail. 2003;25(5):775\u2013786.","DOI":"10.1081\/JDI-120024293"},{"key":"1599_CR9","doi-asserted-by":"publisher","unstructured":"Kumada Y, Yoshitani K, Shimabara Y , Ohnishi Y. Perioperative risk factors for acute kidney injury after off-pump coronary artery bypass grafting: a retrospective study.JA Clin Rep. 2017;3(1):55. doi: https:\/\/doi.org\/10.1186\/s40981-017-0125-2. Epub 2017 Oct 4.","DOI":"10.1186\/s40981-017-0125-2"},{"key":"1599_CR10","doi-asserted-by":"crossref","unstructured":"Mehta RL,Kellum JA,Shah SV, Molitoris BA, Ronco C, Warnock DG,et al.Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury.Crit Care,2007;11:R31.","DOI":"10.1186\/cc5713"},{"key":"1599_CR11","doi-asserted-by":"crossref","unstructured":"Luo X,Jiang L,Du B, Wen Y, Wang M, Xi X,et al.A comparison of different diagnostic criteria of acute kidney injury in critically ill patients.Crit Care.2014;18(4):R144.","DOI":"10.1186\/cc13977"},{"key":"1599_CR12","doi-asserted-by":"crossref","unstructured":"Li SY,Chen JY,Yang WC, Chuang CL.Acute kidney injury network classification predicts in-hospital and long-term mortality in patients undergoing elective coronary artery bypass grafting surgery.Eur J Cardiothorac Surg.2011,39(3):323\u2013328.","DOI":"10.1016\/j.ejcts.2010.07.010"},{"issue":"9","key":"1599_CR13","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604\u201312.","journal-title":"Ann Intern Med"},{"key":"1599_CR14","unstructured":"Zhang Hong,Xia Jie,Xie Yuewen,Qiang Wang.The effect of massive blood transfusion on immune function and inflammatory response of traumatic patients.Chinese Journal of Health Inspection,2018,28(14):1744\u20131746"},{"key":"1599_CR15","doi-asserted-by":"crossref","unstructured":"Olsson D, Sartipy U, Braunschweig F, Holzmann MJ. Acute kidney injury following coronary artery bypass surgery and long-term risk of heart failure. Circ Heart Fail,2013;6:83\u201390. 17.Mariscalco G, Cottini M, Dominici C,Banach M, Piffaretti G, Borsani P,et al. The effect of timing of cardiac catheterization on acute kidney injury after cardiac surgery is influenced by the type of operation.Int J Cardiol 2014;173:46\u201354.","DOI":"10.1161\/CIRCHEARTFAILURE.112.971705"},{"key":"1599_CR16","doi-asserted-by":"crossref","unstructured":"Kiers HD, van den Boogaard M, Schoenmakers MC,van der Hoeven JG,van Swieten HA,Heemskerk S,et al. Comparison and clinical suitability of eight prediction models for cardiac surgery-related acute kidney injury.Nephrol Dial Transplant,2013;28:345\u2013351.","DOI":"10.1093\/ndt\/gfs518"},{"key":"1599_CR17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jcrc.2012.12.008","volume":"28","author":"AJ Bastin","year":"2013","unstructured":"Bastin AJ, Ostermann M, Slack AJ, Diller GP, Finney SJ, Evans TW, et al. Acute kidney injury after cardiac surgery according to Risk\/ Injury\/Failure\/Loss\/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications. J Crit Care. 2013;28:389\u201396.","journal-title":"J Crit Care"},{"key":"1599_CR18","doi-asserted-by":"publisher","unstructured":"Jha V,AriciM,Collins AJ,Garcia-Garcia G,Hemmelgarn BR,Jafar TH,et al.Understanding kidney care needs and implementation strategies in low- and middle-income countries: conclusions from a \"Kidney Disease: Improving Global Outcomes\" (KDIGO) Controversies Conference. Kidney Int. 2016;90(6):1164\u20131174. doi: https:\/\/doi.org\/10.1016\/j.kint.2016.09.009.","DOI":"10.1016\/j.kint.2016.09.009"},{"key":"1599_CR19","doi-asserted-by":"crossref","unstructured":"Solmaz F, Fariba MB, Eissa B,\u00a0Sona A,\u00a0Moussa M,\u00a0Bahman N.Prophylactic furosemide infusion decreasing early major postoperative renal dysfunction in on-pump adult cardiac surgery: a randomized clinical trial.Res Rep Urol. 2017,19(9):5\u201313.","DOI":"10.2147\/RRU.S126134"},{"key":"1599_CR20","doi-asserted-by":"crossref","unstructured":"Lassnigg A, Donner E, Grubhofer G, Presterl E, Druml W, Hiesmayr M.Lack of renoprotective effects of dopamine and furosemide during cardiac surgery.J Am Soc Nephrol. 2000;11(1):97\u2013104.","DOI":"10.1681\/ASN.V11197"},{"key":"1599_CR21","unstructured":"Bayat F, Faritous Z, Aghdaei N, Dabbagh A.A study of the efficacy of furosemide as a prophylaxis of acute renal failure in coronary artery bypass grafting patients: A clinical trial.ARYA Atheroscler. 2015;11(3):173\u2013178."},{"key":"1599_CR22","doi-asserted-by":"crossref","unstructured":"Mehta RL,Pascual MT,Soroko S.Diuretics, mortality, and nonrecovery of renal function in acute renal failure.JAMA.2002;288(20):2547\u20132553.","DOI":"10.1001\/jama.288.20.2547"},{"issue":"5","key":"1599_CR23","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1081\/JDI-120024293","volume":"25","author":"R Lombardi","year":"2003","unstructured":"Lombardi R, Ferreiro A, Servetto C. Renal function after cardiac surgery: adverse effect of furosemide. Ren Fail. 2003;25(5):775\u201386.","journal-title":"Ren Fail"},{"issue":"6","key":"1599_CR24","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1093\/icvts\/ivy353","volume":"28","author":"Z Li","year":"2019","unstructured":"Li Z, Fan G, Zheng X, Gong X, Chen T, Liu X, et al. Risk factors and clinical significance of acute kidney injury after on-pump or off-pump coronary artery bypass grafting: a propensity score-matched study. Interact Cardiovasc Thorac Surg. 2019;28(6):893\u20139. https:\/\/doi.org\/10.1093\/icvts\/ivy353.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"1599_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.21470\/1678-9741-2017-0209","volume":"34","author":"S Amini","year":"2019","unstructured":"Amini S, Najafi MN, Karrari SP, Mashhadi ME, Mirzaei S, et al. Risk Factors and Outcome of Acute Kidney Injury after Isolated CABG Surgery: a Prospective Cohort Study. Braz J Cardiovasc Surg. 2019;34(1):70\u20135. https:\/\/doi.org\/10.21470\/1678-9741-2017-0209.","journal-title":"Braz J Cardiovasc Surg"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01599-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-021-01599-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01599-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T21:53:49Z","timestamp":1630706029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-021-01599-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,6]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1599"],"URL":"https:\/\/doi.org\/10.1007\/s11748-021-01599-0","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"value":"1863-6705","type":"print"},{"value":"1863-6713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,6]]},"assertion":[{"value":"5 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}