{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:24:44Z","timestamp":1780428284775,"version":"3.54.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11748-021-01611-7","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T05:31:56Z","timestamp":1616477516000},"page":"1214-1221","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Surgical outcomes of pulmonary metastasectomy for head and neck cancer in the current era of advances in chemotherapy and immunotherapy"],"prefix":"10.1007","volume":"69","author":[{"given":"Takahiro","family":"Ochi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-4886","authenticated-orcid":false,"given":"Hironobu","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Sakairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syuji","family":"Yonekura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyoyuki","family":"Hanazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"1611_CR1","first-page":"67","volume":"2","author":"NCC Network","year":"2020","unstructured":"Network NCC. NCCN clinical practice guidelines in oncology (NCCN guidelines\u00ae). Head Neck Cancers Version. 2020;2:67\u20139.","journal-title":"Head Neck Cancers Version"},{"key":"1611_CR2","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1245\/s10434-008-0001-4","volume":"15","author":"H Winter","year":"2008","unstructured":"Winter H, Meimarakis G, Hoffmann G, Hummel M, R\u00fcttinger D, Zilbauer A, et al. Does surgical resection of pulmonary metastases of head and neck cancer improve survival? Ann Surg Oncol. 2008;15:2915\u201326.","journal-title":"Ann Surg Oncol"},{"key":"1611_CR3","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1007\/s00268-008-9631-8","volume":"32","author":"F Chen","year":"2008","unstructured":"Chen F, Sonobe M, Sato K, Fujinaga T, Shoji T, Sakai H, et al. Pulmonary resection for metastatic head and neck cancer. World J Surg. 2008;32:1657\u201362.","journal-title":"World J Surg"},{"key":"1611_CR4","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.athoracsur.2009.04.040","volume":"88","author":"S Shiono","year":"2009","unstructured":"Shiono S, Kawamura M, Sato T, Okumura S, Nakajima J, Yoshino I, et al. Pulmonary metastasectomy for pulmonary metastases of head and neck squamous cell carcinomas. Ann Thorac Surg. 2009;88:856\u201360.","journal-title":"Ann Thorac Surg"},{"key":"1611_CR5","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1093\/jjco\/hyq023","volume":"40","author":"H Daiko","year":"2010","unstructured":"Daiko H, Nagai K, Yoshida J, Nishimura M, Hishida T, Ebihara M, et al. The role of pulmonary resection in tumors metastatic from head and neck carcinomas. Jpn J Clin Oncol. 2010;40:639\u201344.","journal-title":"Jpn J Clin Oncol"},{"key":"1611_CR6","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1510\/icvts.2009.219766","volume":"10","author":"A Haro","year":"2010","unstructured":"Haro A, Yano T, Yoshida T, Ito K, Morodomi Y, Shoji F, et al. Results of a surgical resection of pulmonary metastasis from malignant head and neck tumor. Interact Cardiovasc Thorac Surg. 2010;10:700\u20133.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"1611_CR7","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/hed.23232","volume":"35","author":"T Miyazaki","year":"2013","unstructured":"Miyazaki T, Hasegawa Y, Hanai N, Ozawa T, Hirakawa H, Suzuki A, et al. Survival impact of pulmonary metastasectomy for patients with head and neck cancer. Head Neck. 2013;35:1745\u201351.","journal-title":"Head Neck"},{"key":"1611_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s12070-014-0799-y","volume":"67","author":"K Yamazaki","year":"2015","unstructured":"Yamazaki K, Shodo R, Ueki Y, Matsuyama H, Takahashi S. Therapeutic outcome after resection of pulmonary metastasis from head and neck carcinomas. Indian J Otolaryngol Head Neck Surg. 2015;67:124\u20138.","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"1611_CR9","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/1759-7714.12225","volume":"6","author":"M Yotsukura","year":"2015","unstructured":"Yotsukura M, Kinoshita T, Kohno M, Asakura K, Kamiyama I, Emoto K, et al. Survival predictors after resection of lung metastases of head or neck cancers. Thorac Cancer. 2015;6:579\u201383.","journal-title":"Thorac Cancer"},{"key":"1611_CR10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5761\/atcs.oa.16-00269","volume":"23","author":"Y Nakajima","year":"2017","unstructured":"Nakajima Y, Iijima Y, Kinoshita H, Akiyama H, Beppu T, Uramoto H, et al. Surgical treatment for pulmonary metastasis of head and neck cancer: study of 58 cases. Ann Thorac Cardiovasc Surg. 2017;23:169\u201374.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"1611_CR11","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.suronc.2018.04.007","volume":"27","author":"S Okada","year":"2018","unstructured":"Okada S, Itoh K, Ishihara S, Shimada J, Kato D, Tsunezuka H, et al. Significance of PD-L1 expression in pulmonary metastases from head and neck squamous cell carcinoma. Surg Oncol. 2018;27:259\u201365.","journal-title":"Surg Oncol"},{"key":"1611_CR12","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1093\/ejcts\/ezy384","volume":"55","author":"T Oki","year":"2019","unstructured":"Oki T, Hishida T, Yoshida J, Goto M, Sekihara K, Miyoshi T, et al. Survival and prognostic factors after pulmonary metastasectomy of head and neck cancer: what are the clinically informative prognostic indicators? Eur J Cardiothorac Surg. 2019;55:942\u20137.","journal-title":"Eur J Cardiothorac Surg"},{"key":"1611_CR13","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","volume":"359","author":"JB Vermorken","year":"2008","unstructured":"Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359:1116\u201327.","journal-title":"N Engl J Med"},{"key":"1611_CR14","doi-asserted-by":"publisher","first-page":"8646","DOI":"10.1200\/JCO.2005.02.4646","volume":"23","author":"B Burtness","year":"2005","unstructured":"Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic\/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 2005;23:8646\u201354.","journal-title":"J Clin Oncol"},{"key":"1611_CR15","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","volume":"375","author":"RL Ferris","year":"2016","unstructured":"Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, et al. Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med. 2016;375:1856\u201367.","journal-title":"N Engl J Med"},{"key":"1611_CR16","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S1470-2045(16)30066-3","volume":"17","author":"TY Seiwert","year":"2016","unstructured":"Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol. 2016;17:956\u201365.","journal-title":"Lancet Oncol"},{"key":"1611_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1378\/chest.73.2.163","volume":"73","author":"PM McCormack","year":"1978","unstructured":"McCormack PM, Bains MS, Beattie EJ Jr, Martini N. Pulmonary resection in metastatic carcinoma. Chest. 1978;73:163\u20136.","journal-title":"Chest"},{"key":"1611_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/coa.12348","volume":"40","author":"ER Young","year":"2015","unstructured":"Young ER, Diakos E, Khalid-Raja M, Mehanna H. Resection of subsequent pulmonary metastases from treated head and neck squamous cell carcinoma: systematic review and meta-analysis. Clin Otolaryngol. 2015;40:208\u201318.","journal-title":"Clin Otolaryngol"},{"key":"1611_CR19","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1158\/1078-0432.CCR-08-1968","volume":"15","author":"TW Geurts","year":"2009","unstructured":"Geurts TW, van Velthuysen ML, Broekman F, van Huysduynen TH, van den Brekel MW, van Zandwijk N, et al. Differential diagnosis of pulmonary carcinoma following head and neck cancer by genetic analysis. Clin Cancer Res. 2009;15:980\u20135.","journal-title":"Clin Cancer Res"},{"key":"1611_CR20","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.lungcan.2016.08.003","volume":"100","author":"J Ichinose","year":"2016","unstructured":"Ichinose J, Shinozaki-Ushiku A, Nagayama K, Nitadori JI, Anraku M, Fukayama M, et al. Immunohistochemical pattern analysis of squamous cell carcinoma: lung primary and metastatic tumors of head and neck. Lung Cancer. 2016;100:96\u2013101.","journal-title":"Lung Cancer"},{"key":"1611_CR21","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.jtcvs.2017.02.071","volume":"154","author":"JA Mu\u00f1oz-Largacha","year":"2017","unstructured":"Mu\u00f1oz-Largacha JA, Gower AC, Sridhar P, Deshpande A, O\u2019Hara CJ, Yamada E, et al. miRNA profiling of primary lung and head and neck squamous cell carcinomas: addressing a diagnostic dilemma. J Thorac Cardiovasc Surg. 2017;154:714\u201327.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1611_CR22","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708428","author":"H Bohnenberger","year":"2018","unstructured":"Bohnenberger H, Kaderali L, Str\u00f6bel P, Yepes D, Plessmann U, Dharia NV, et al. Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis. EMBO Mol Med. 2018. https:\/\/doi.org\/10.15252\/emmm.201708428.","journal-title":"EMBO Mol Med"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01611-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-021-01611-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01611-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T17:20:33Z","timestamp":1626369633000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-021-01611-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1611"],"URL":"https:\/\/doi.org\/10.1007\/s11748-021-01611-7","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"value":"1863-6705","type":"print"},{"value":"1863-6713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"30 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}