{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:42:44Z","timestamp":1782999764522,"version":"3.54.5"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. We present the case of a 44-year-old man who underwent a surgery for a perforated small intestine. Compued tomography scan revealed a tissular mediastino\u2013pulmonary mass.<\/jats:p><jats:p>Histopathological examination of the intestinal mass shown a malignant tumour with a typical epithelioid and rhabdoid cells, numerous mitoses and large necrosis. A large panel of immunohistochemistry revealed loss of SMARCA4 and SMARCA2 and allowed the diagnosis of SMARCA4-DTS. It is important to consider SMARCA4-deficient thoracic sarcoma in the differential diagnosis of tumours showing suggestive morphologic features in patients of all ages, especially in the case of metastasis associated with thoracic mass.<\/jats:p>","DOI":"10.1007\/s11748-021-01627-z","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T17:02:37Z","timestamp":1618678957000},"page":"1155-1158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["SMARCA4-deficient thoracic sarcoma revealed by metastasis to the small intestine: a diagnostic dilemma"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-1053","authenticated-orcid":false,"given":"Fatma","family":"Khanchel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raweh","family":"Hedhili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakim","family":"Zenaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelwahed","family":"Yahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend","family":"Ben N\u00e9ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feryel","family":"Ksontini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsen","family":"Ben Brahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Jouini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aschraf","family":"Chadli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,17]]},"reference":[{"key":"1627_CR1","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/ng.3399","volume":"47","author":"F Le Loarer","year":"2015","unstructured":"Le Loarer F, Watson S, Pierron G, de Montpreville VT, Ballet S, Firmin N, et al. SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas. Nat Genet. 2015;47:1200\u20135. https:\/\/doi.org\/10.1038\/ng.3399.","journal-title":"Nat Genet"},{"key":"1627_CR2","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/modpathol.2017.11","volume":"30","author":"A Yoshida","year":"2017","unstructured":"Yoshida A, Kobayashi E, Kubo T, Kodaira M, Motoi T, Motoi N, et al. Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. Mod Pathol. 2017;30:797\u2013809. https:\/\/doi.org\/10.1038\/modpathol.2017.11.","journal-title":"Mod Pathol"},{"key":"1627_CR3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrc1273","volume":"4","author":"CWM Roberts","year":"2004","unstructured":"Roberts CWM, Orkin SH. The SWI\/SNF complex\u2014chromatin and cancer. 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Accessed 11 May 2020","DOI":"10.1111\/cup.13652."},{"key":"1627_CR6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.lungcan.2019.03.029","volume":"132","author":"K Kunimasa","year":"2019","unstructured":"Kunimasa K, Nakamura H, Sakai K, Tamiya M, Kimura M, Inoue T, et al. Patients with SMARCA4-deficient thoracic sarcoma and severe skeletal-related events. Lung Cancer. 2019;132:59\u201364. https:\/\/doi.org\/10.1016\/j.lungcan.2019.03.029.","journal-title":"Lung Cancer"},{"key":"1627_CR7","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1038\/modpathol.2017.61","volume":"30","author":"JL Sauter","year":"2017","unstructured":"Sauter JL, Graham RP, Larsen BT, Jenkins SM, Roden AC, Boland JM. SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior. Mod Pathol. 2017;30:1422\u201332. https:\/\/doi.org\/10.1038\/modpathol.2017.61.","journal-title":"Mod Pathol."},{"key":"1627_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/PAS.0000000000001188","volume":"43","author":"R Perret","year":"2019","unstructured":"Perret R, Chalabreysse L, Watson S, Serre I, Garcia S, Forest F, et al. SMARCA4-deficient thoracic sarcomas: clinicopathologic study of 30 cases with an emphasis on their nosology and differential diagnoses. Am J Surg Pathol. 2019;43:455\u201365. https:\/\/doi.org\/10.1097\/PAS.0000000000001188.","journal-title":"Am J Surg Pathol"},{"key":"1627_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jtho.2019.10.023","volume":"15","author":"N Rekhtman","year":"2020","unstructured":"Rekhtman N, Montecalvo J, Chang JC, Alex D, Ptashkin RN, Ai N, et al. SMARCA4-deficient thoracic sarcomatoid tumors represent primarily smoking-related undifferentiated carcinomas rather than primary thoracic sarcomas. J Thorac Oncol. 2020;15:231\u201347. https:\/\/doi.org\/10.1016\/j.jtho.2019.10.023.","journal-title":"J Thorac Oncol"},{"key":"1627_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1177\/1066896919870866","volume":"28","author":"M Takeda","year":"2020","unstructured":"Takeda M, Tani Y, Saijo N, Shimizu S, Taniguchi Y, Otsuka K, et al. Cytopathological features of SMARCA4-deficient thoracic sarcoma: report of 2 cases and review of the literature. 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