{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:28:29Z","timestamp":1784298509202,"version":"3.55.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study aimed to compare the short-term outcomes of transcatheter and surgical aortic valve replacements (TAVR and SAVR) in high-, intermediate-, and low-preoperative risk patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 454 patients who underwent TAVR or SAVR were included. Patients were categorized into high-, intermediate-, and low-risk according to the Society of Thoracic Surgery-Predicted Risk of Mortality score and clinical outcomes were compared between TAVR and SAVR groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>TAVR was less invasive, with less bleeding and transfusion (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), less frequent new-onset atrial fibrillation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and shorter intensive care unit stay (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, transcatheter valves performed better than surgical valves, with lower peak velocity (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and pressure gradient (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and higher effective orifice area index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The clinical outcomes of TAVR were comparable to or even superior to those of SAVR in high- and intermediate-risk patients. In low-risk patients, the 1- and 2-year mortality rates were 6.3% and 12.1%, respectively, in the TAVR group and 0% and 0.9%, respectively, in the SAVR group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mild or greater paravalvular leakage was a risk factor for mortality (hazard ratio 35.78; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TAVR was superior to SAVR in the sense of less invasiveness and valvular function. However, the indication of TAVR in low-risk patients should be carefully discussed, because paravalvular leakage was a risk factor for short-term mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11748-021-01672-8","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T18:05:59Z","timestamp":1624385159000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Contemporary short-term outcomes of surgery for aortic stenosis: transcatheter vs. surgical aortic valve replacement"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-2891","authenticated-orcid":false,"given":"Shunsuke","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimi","family":"Sairenchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tezuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Monta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Shibasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"issue":"17","key":"1672_CR1","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","volume":"363","author":"MB Leon","year":"2010","unstructured":"Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363(17):1597\u2013607.","journal-title":"N Engl J Med"},{"issue":"23","key":"1672_CR2","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","volume":"364","author":"CR Smith","year":"2011","unstructured":"Smith CR, Leon MB, Mack MJ, Miller DC, Moses JW, Svensson LG, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364(23):2187\u201398.","journal-title":"N Engl J Med"},{"issue":"19","key":"1672_CR3","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1056\/NEJMoa1400590","volume":"370","author":"DH Adams","year":"2014","unstructured":"Adams DH, Popma JJ, Reardon MJ, Yakubov SJ, Coselli JS, Deeb GM, et al. Transcatheter aortic-valve replacement with a self-expanding prosthesis. N Engl J Med. 2014;370(19):1790\u20138.","journal-title":"N Engl J Med"},{"issue":"17","key":"1672_CR4","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","volume":"374","author":"MB Leon","year":"2016","unstructured":"Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK, et al. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2016;374(17):1609\u201320.","journal-title":"N Engl J Med"},{"issue":"14","key":"1672_CR5","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","volume":"376","author":"MJ Reardon","year":"2017","unstructured":"Reardon MJ, Van Mieghem NM, Popma JJ, Kleiman NS, S\u00f8ndergaard L, Mumtaz M, et al. Surgical or transcatheter aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2017;376(14):1321\u201331.","journal-title":"N Engl J Med"},{"issue":"18","key":"1672_CR6","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","volume":"380","author":"MJ Mack","year":"2019","unstructured":"Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo M, et al. Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med. 2019;380(18):1695\u2013705.","journal-title":"N Engl J Med"},{"issue":"18","key":"1672_CR7","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","volume":"380","author":"JJ Popma","year":"2019","unstructured":"Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O\u2019Hair D, et al. Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients. N Engl J Med. 2019;380(18):1706\u201315.","journal-title":"N Engl J Med"},{"issue":"36","key":"1672_CR8","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","volume":"38","author":"H Baumgartner","year":"2017","unstructured":"Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, et al. 2017 ESC\/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739\u201391.","journal-title":"Eur Heart J"},{"issue":"11","key":"1672_CR9","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1253\/circj.CJ-20-0135","volume":"84","author":"C Izumi","year":"2020","unstructured":"Izumi C, Eishi K, Ashihara K, Arita T, Otsuji Y, Kunihara T, et al. JCS\/JSCS\/JATS\/JSVS 2020 guidelines on the management of valvular heart disease. Circulation. 2020;84(11):2037\u2013119.","journal-title":"Circulation"},{"issue":"9","key":"1672_CR10","first-page":"014327","volume":"6","author":"L Lytvyn","year":"2016","unstructured":"Lytvyn L, Guyatt GH, Manja V, Siemieniuk RA, Zhang Y, Agoritsas T, et al. Patient values and preferences on transcatheter or surgical aortic valve replacement therapy for aortic stenosis: a systematic review. BMJ. 2016;6(9):014327.","journal-title":"BMJ"},{"issue":"Suppl 2","key":"1672_CR11","doi-asserted-by":"publisher","first-page":"s44","DOI":"10.1136\/heartjnl-2018-313518","volume":"105","author":"J Gunn","year":"2019","unstructured":"Gunn J, Taggart DP. Transcatheter versus surgical intervention: lessons from trials of coronary revascularisation. Heart. 2019;105(Suppl 2):s44\u20139.","journal-title":"Heart"},{"issue":"4","key":"1672_CR12","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1007\/s12055-019-00835-w","volume":"35","author":"P Narayan","year":"2019","unstructured":"Narayan P. Transcatheter aortic valve replacement in low-risk patients: superiority or shifting goalposts and statistical crystal-gazing? Indian J Thorac Cardiovasc Surg. 2019;35(4):596\u20138.","journal-title":"Indian J Thorac Cardiovasc Surg"},{"issue":"8","key":"1672_CR13","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1053\/j.jvca.2020.02.045","volume":"34","author":"F Onorati","year":"2020","unstructured":"Onorati F, Quintana E, El-Dean Z, Perrotti A, Sponga S, Ruggieri VG, et al. Aortic valve replacement for aortic stenosis in low-, intermediate-, and high-risk patients: preliminary results from a prospective multicenter registry. J Cardiothorac Vasc Anesth. 2020;34(8):2091\u20139.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"1672_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1253\/circj.CJ-19-0951","volume":"84","author":"Y Takeji","year":"2020","unstructured":"Takeji Y, Taniguchi T, Morimoto T, Saito N, Ando K, Shirai S, et al. Transcatheter aortic valve implantation vs. surgical aortic valve replacement for severe aortic stenosis in real-world clinical practice. Circulation. 2020;84(5):806\u201314.","journal-title":"Circulation"},{"issue":"3","key":"1672_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013;48(3):452\u20138.","journal-title":"Bone Marrow Transplant"},{"issue":"18","key":"1672_CR16","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1056\/NEJMoa1200384","volume":"366","author":"SK Kodali","year":"2012","unstructured":"Kodali SK, Williams MR, Smith CR, Svensson LG, Webb JG, Makkar RR, et al. Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med. 2012;366(18):1686\u201395.","journal-title":"N Engl J Med"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01672-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-021-01672-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01672-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T13:10:31Z","timestamp":1644066631000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-021-01672-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1672"],"URL":"https:\/\/doi.org\/10.1007\/s11748-021-01672-8","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"value":"1863-6705","type":"print"},{"value":"1863-6713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"19 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Saito S has no conflict of interest; Sairenchi T has no conflict of interest; Tezuka M has no conflict of interest; Takei Y has no conflict of interest; Tsuchiya G has no conflict of interest; Ogata K has no conflict of interest; Monta O has no conflict of interest; Shibasaki I has no conflict of interest; Tsutsumi Y has no conflict of interest; Fukuda H has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}