{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:23:49Z","timestamp":1788477829523,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carney complex is a rare syndrome caused by a genetic mutation leading to multiple endocrine abnormalities and a variety of tumors. Here, we report a case of Carney complex diagnosed due to recurrent multiple myxomas in the right atrium of a patient 16\u00a0years after the resection of the primary left atrial myxoma. Surgical excision was performed for the multiple recurrent right atrial tumors under cardiopulmonary bypass. The patient remained complication-free after surgery and was discharged on the 14th day. He was scheduled to continue echocardiographic follow-up and periodic systemic review by an endocrinologist. This case emphasizes the fact that if cardiac myxomas tend to be multiple and recurrent at a relatively young age, the possibility of Carney complex should be considered, even in the absence of any other related feature other than cardiac tumors.<\/jats:p>","DOI":"10.1007\/s11748-021-01719-w","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T03:48:05Z","timestamp":1634096885000},"page":"87-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnosis of Carney complex following multiple recurrent cardiac myxomas"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-3392","authenticated-orcid":false,"given":"Shigeki","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanetsugu","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Higashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Fukahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"1719_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/00000478-198501000-00009","volume":"9","author":"JA Carney","year":"1985","unstructured":"Carney JA. Differences between nonfamilial and familial cardiac myxoma. Am J Surg Pathol. 1985;9:53\u20135.","journal-title":"Am J Surg Pathol"},{"key":"1719_CR2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/00005792-198507000-00007","volume":"64","author":"JA Carney","year":"1985","unstructured":"Carney JA, Gordon H, Carpenter PC, Shenoy BV, Go VL. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Med (Baltim). 1985;64:270\u201383.","journal-title":"Med (Baltim)"},{"key":"1719_CR3","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1210\/jcem.86.9.7903","volume":"86","author":"CA Stratakis","year":"2001","unstructured":"Stratakis CA, Kirschner LS, Carney JA. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab. 2001;86:4041\u20136.","journal-title":"J Clin Endocrinol Metab"},{"key":"1719_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/79238","volume":"26","author":"LS Kirschner","year":"2000","unstructured":"Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, et al. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet. 2000;26:89\u201392.","journal-title":"Nat Genet"},{"key":"1719_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00000658-198002000-00001","volume":"191","author":"NA Silverman","year":"1980","unstructured":"Silverman NA. Primary cardiac tumors. Ann Surg. 1980;191:127\u201338.","journal-title":"Ann Surg"},{"key":"1719_CR6","doi-asserted-by":"publisher","first-page":"R99","DOI":"10.1530\/EJE-20-1120","volume":"184","author":"L Bouys","year":"2021","unstructured":"Bouys L, Bertherat J. Management of endocrine disease: Carney complex: clinical and genetic update 20 years after the identification of the CNC1 (PRKAR1A) gene. Eur J Endocrinol. 2021;184:R99-109. https:\/\/doi.org\/10.1530\/EJE-20-1120.","journal-title":"Eur J Endocrinol"},{"key":"1719_CR7","doi-asserted-by":"publisher","unstructured":"Siordia JA. Medical and surgical management of Carney complex. J Card Surg. 2015; 30: 560\u20137. doi: https:\/\/doi.org\/10.1111\/jocs.12575. [Epub 2015 May 21]. PMID: 25996461","DOI":"10.1111\/jocs.12575"},{"key":"1719_CR8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/s1525-2167(03)00018-0","volume":"4","author":"K Hermans","year":"2003","unstructured":"Hermans K, Jaarsma W, Plokker HW, Cramer MJ, Morshuis WJ. Four cardiac myxomas diagnosed three times in one patient. Eur J Echocardiogr. 2003;4:336\u20138. https:\/\/doi.org\/10.1016\/s1525-2167(03)00018-0 (PMID: 14611833).","journal-title":"Eur J Echocardiogr"},{"key":"1719_CR9","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/1749-8090-8-222","volume":"8","author":"S Marinakis","year":"2013","unstructured":"Marinakis S, Mircev D, Wauthy P. Cryoablation for a right atrial myxoma arising from the Koch\u2019s triangle: a case report. J Cardiothorac Surg. 2013;8:222. https:\/\/doi.org\/10.1186\/1749-8090-8-222.","journal-title":"J Cardiothorac Surg"},{"key":"1719_CR10","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/j.athoracsur.2007.11.080","volume":"85","author":"KS Rathore","year":"2008","unstructured":"Rathore KS, Hussenbocus S, Stuklis R, Edwards J. Novel strategies for recurrent cardiac myxoma. Ann Thorac Surg. 2008;85:2125\u20136. https:\/\/doi.org\/10.1016\/j.athoracsur.2007.11.080 (PMID: 18498840).","journal-title":"Ann Thorac Surg"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01719-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-021-01719-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-021-01719-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T19:12:04Z","timestamp":1641409924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-021-01719-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["1719"],"URL":"https:\/\/doi.org\/10.1007\/s11748-021-01719-w","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"value":"1863-6705","type":"print"},{"value":"1863-6713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,12]]},"assertion":[{"value":"4 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest statement"}}]}}