{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:43:47Z","timestamp":1766731427277,"version":"3.41.2"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Air leakage during pulmonary resection is a major complication in thoracic surgery. It frequently occurs at sites of adhesion dissection, due to lung manipulation, and along the staple lines of automatic suturing devices, particularly in cases of pulmonary fragility such as those of emphysema and interstitial pneumonia. Persistent postoperative air leakage prolongs chest tube indwelling and extends hospitalization time. Staplers with absorbable tissue reinforcements have been introduced for pulmonary resection to prevent intraoperative stapler-related air leakage. This phase II prospective, open-label, randomized, parallel-group trial aims to validate the efficacy of staplers with or without absorbable tissue reinforcements in controlling stapler-related air leakage during anatomical pulmonary resections.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Overall, 120 patients will be randomized into two groups: one that will undergo conventional anatomical pulmonary resection and the other in which staplers with absorbable tissue reinforcements will be used. The primary endpoint will be intraoperative stapler-related air leakage. Data will be analyzed between 2024 and 2025.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>This trial will validate the effectiveness and safety of staple line reinforcements in controlling intraoperative air leakage during anatomical pulmonary resections, potentially leading to optimized strategies for patients with conditions such as emphysema and interstitial pneumonia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>This trial has been registered with the Japan Registry of Clinical Trials 1032220620 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/jrct.niph.go.jp\/latest-detail\/jRCTs031230224\" ext-link-type=\"uri\">https:\/\/jrct.niph.go.jp\/latest-detail\/jRCTs031230224<\/jats:ext-link>).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11748-024-02111-0","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T23:09:07Z","timestamp":1735168147000},"page":"616-621","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating air leakage from staple line reinforcements in anatomical pulmonary resection (AIRSTOP): a prospective randomized controlled trial protocol"],"prefix":"10.1007","volume":"73","author":[{"given":"Jotaro","family":"Yusa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Shiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"2111_CR1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ejcts.2004.11.004","volume":"27","author":"AJ Stolz","year":"2005","unstructured":"Stolz AJ, Sch\u00fctzner J, Lischke R, Simonek J, Pafko P. Predictors of prolonged air leak following pulmonary lobectomy. Eur J Cardiothorac Surg. 2005;27:334\u20136. https:\/\/doi.org\/10.1016\/j.ejcts.2004.11.004.","journal-title":"Eur J Cardiothorac Surg"},{"key":"2111_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00595-021-02300-x","volume":"52","author":"Y Shintani","year":"2022","unstructured":"Shintani Y, Yamamoto H, Sato Y, Shimizu K, Endo S, Okada M, et al. A risk model for prolonged air leak after lobectomy using the National Clinical Database in Japan. Surg Today. 2022;52:69\u201374. https:\/\/doi.org\/10.1007\/s00595-021-02300-x.","journal-title":"Surg Today"},{"key":"2111_CR3","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1016\/j.asjsur.2022.01.001","volume":"45","author":"Q Zheng","year":"2022","unstructured":"Zheng Q, Ge L, Zhou J, Zhang Y, Lyu M, Chen C, et al. Risk factors for prolonged air leak after pulmonary surgery: a systematic review and meta-analysis. Asian J Surg. 2022;45:2159\u201367. https:\/\/doi.org\/10.1016\/j.asjsur.2022.01.001.","journal-title":"Asian J Surg"},{"key":"2111_CR4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/s0003-4975(00)02203-7","volume":"71","author":"JI Miller","year":"2001","unstructured":"Miller JI, Landreneau RJ, Wright CE, Santucci TS, Sammons BH. A comparative study of buttressed versus nonbuttressed staple line in pulmonary resections. Ann Thorac Surg. 2001;71:319\u201322. https:\/\/doi.org\/10.1016\/s0003-4975(00)02203-7.","journal-title":"Ann Thorac Surg"},{"key":"2111_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jss.2005.06.007","volume":"131","author":"DM Downey","year":"2006","unstructured":"Downey DM, Michel M, Harre JG, Pratt JW. Functional assessment of a new staple line reinforcement in lung resection. J Surg Res. 2006;131:49\u201352. https:\/\/doi.org\/10.1016\/j.jss.2005.06.007.","journal-title":"J Surg Res"},{"key":"2111_CR6","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.3390\/jcm12072719","volume":"12","author":"C Sassorossi","year":"2023","unstructured":"Sassorossi C, Congedo MT, Nachira D, Tabacco D, Chiappetta M, Evangelista J, et al. Reducing post-operative alveolo-pleural fistula by applying PGA-sheets (neoveil) after major lung resection: a historical case-control study. J Clin Med. 2023;12:2719. https:\/\/doi.org\/10.3390\/jcm12072719.","journal-title":"J Clin Med"},{"key":"2111_CR7","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.21037\/jtd.2019.03.05","volume":"11","author":"W Shigeeda","year":"2019","unstructured":"Shigeeda W, Deguchi H, Tomoyasu M, Kaneko Y, Kanno H, Tanita T, et al. The utility of the Stapler with PGA sheet for pulmonary wedge resection: a propensity score-matched analysis. J Thorac Dis. 2019;11:1546\u201353. https:\/\/doi.org\/10.21037\/jtd.2019.03.05.","journal-title":"J Thorac Dis"},{"key":"2111_CR8","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.21037\/jtd.2017.03.109","volume":"9","author":"D Zhang","year":"2017","unstructured":"Zhang D, Miao J, Hu X, Hu B, Li H. A clinical study of efficacy of polyglycolic acid sleeve after video-assisted thoracoscopic bullectomy for primary spontaneous pneumothorax. J Thorac Dis. 2017;9:1093\u20139. https:\/\/doi.org\/10.21037\/jtd.2017.03.109.","journal-title":"J Thorac Dis"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-024-02111-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-024-02111-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-024-02111-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:40:32Z","timestamp":1753357232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-024-02111-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["2111"],"URL":"https:\/\/doi.org\/10.1007\/s11748-024-02111-0","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"type":"print","value":"1863-6705"},{"type":"electronic","value":"1863-6713"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"7 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors have completed the ICMJE Uniform Disclosure Form and declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors are accountable for all aspects of the work and for ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study will be conducted in accordance with the Declaration of Helsinki (revised in 2013). It has been approved by the Chiba University Certified Clinical Research Review Board (CRB3180015) and registered with the Japan Registry of Clinical Trials (jRCT1032220620). The investigators will explain the concept of the trial to the patients and obtain written informed consent from each patients, including consent for the use of their data in study publications.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}