{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:20:04Z","timestamp":1768519204901,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s11748-025-02153-y","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T07:20:28Z","timestamp":1746256828000},"page":"795-805","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The utility of neocuspidization in the surgical management of congenital aortic valve pathology: mid-term results of single-center experience with AVNeo procedure in children"],"prefix":"10.1007","volume":"73","author":[{"given":"Igor","family":"Mokryk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Illia","family":"Nechai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Dudko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro","family":"Harbuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihor","family":"Stetsyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borys","family":"Todurov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"issue":"1","key":"2153_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/icvts\/ivaa237.PMCID:PMC8919835","volume":"32","author":"A Polito","year":"2021","unstructured":"Polito A, Albanese SB, Cetrano E, Cicenia M, Rinelli G, Carotti A. Aortic valve neocuspidalization in paediatric patients with isolated aortic valve disease: early experience. Interact Cardiovasc Thorac Surg. 2021;32(1):111\u20137. https:\/\/doi.org\/10.1093\/icvts\/ivaa237.PMCID:PMC8919835. (PMID: 33221849).","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"2153_CR2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.athoracsur.2015.09.088","volume":"102","author":"R Philip","year":"2016","unstructured":"Philip R, Kumar TS, Waller BR, McCoy M, Knott-Craig CJ. Near catastrophic accelerated structural degeneration of the perimount magna pericardial bioprosthesis in children. Ann Thorac Surg. 2016;102(1):308\u201311.","journal-title":"Ann Thorac Surg"},{"key":"2153_CR3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/CIRCULATIONAHA.118.037187","volume":"139","author":"SF Saleeb","year":"2019","unstructured":"Saleeb SF, Gauvreau K, Mayer JE, Newburger JW. Aortic valve replacement with bovine pericardial tissue valve in children and young adults. Circulation. 2019;139:983\u20135.","journal-title":"Circulation"},{"key":"2153_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jtcvs.2018.08.077","volume":"157","author":"PO Myers","year":"2019","unstructured":"Myers PO, Mokashi SA, Horgan E, Borisuk M, Mayer JE Jr, Del Nido PJ, et al. Outcomes after mechanical aortic valve replacement in children and young adults with congenital heart disease. J Thorac Cardiovasc Surg. 2019;157:329\u201340.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2153_CR5","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jtcvs.2007.09.057","volume":"135","author":"EA Bacha","year":"2008","unstructured":"Bacha EA, McElhinney DB, Guleserian KJ, et al. Surgical aortic valvuloplasty in children and adolescents with aortic regurgitation: acute and intermediate effects on aortic valve function and left ventricular dimensions. J Thorac Cardiovasc Surg. 2008;135:552\u20139.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"2153_CR6","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/j.athoracsur.2015.04.056","volume":"100","author":"D Mazzitelli","year":"2015","unstructured":"Mazzitelli D, N\u00f6bauer C, Rankin JS, Vogt M, Lange R, Schreiber C. Complete aortic valve cusp replacement in the pediatric population using tissue-engineered bovine pericardium. Ann Thorac Surg. 2015;100(5):1923\u20135. https:\/\/doi.org\/10.1016\/j.athoracsur.2015.04.056. (PMID: 26522549).","journal-title":"Ann Thorac Surg"},{"key":"2153_CR7","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1136\/heartjnl-2014-305873","volume":"100","author":"GB Luciani","year":"2014","unstructured":"Luciani GB, Lucchese G, Carotti A, Brancaccio G, Abbruzzese P, Caianiello G, et al. Two decades of experience with the Ross operation in neonates, infants, and children from the Italian Paediatric Ross Registry. Heart. 2014;100:1954\u20139.","journal-title":"Heart"},{"key":"2153_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jtcvs.2015.09.083","volume":"151","author":"JRG Etnel","year":"2016","unstructured":"Etnel JRG, Elmont LC, Ertekin E, Mokhles MM, Heuvelman HJ, Roos-Hesselink JW, et al. Outcome after aortic valve replacement in children: a systematic review and meta-analysis. J Thorac Cardiovasc Surg. 2016;151:143\u201352.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"2153_CR9","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5761\/atcs.oa.24-00067","volume":"30","author":"I Mokryk","year":"2024","unstructured":"Mokryk I, Nechai I, Stetsyuk I, Malova N, Demyanchuk V, Todurov B. Complete aortic valve reconstruction with autologous pericardium: analysis of mid-term results of single-center experience with AVNeo procedure. Ann Thorac Cardiovasc Surg. 2024;30(1):24\u201300067. https:\/\/doi.org\/10.5761\/atcs.oa.24-00067.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2153_CR10","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1016\/j.jtcvs.2018.01.087","volume":"155","author":"S Ozaki","year":"2018","unstructured":"Ozaki S, Kawase I, Yamashita H, et al. Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium. J Thorac Cardiovasc Surg. 2018;155:2739\u201387.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2153_CR11","doi-asserted-by":"publisher","first-page":"S385","DOI":"10.1016\/S0003-4975(01)02492-4","volume":"71","author":"P Human","year":"2001","unstructured":"Human P, Zilla P. Characterization of the immune response to valve bioprosthesis and its role in primary tissue failure. Ann Thorac Surg. 2001;71:S385\u20138.","journal-title":"Ann Thorac Surg"},{"key":"2153_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ahj.2022.09.003","volume":"255","author":"KS Mylonas","year":"2023","unstructured":"Mylonas KS, Tasoudis PT, Pavlopoulos D, et al. Aortic valve neocuspidization using Ozaki technique: a meta-analysis of reconstructed patient-level data. Am Heart J. 2023;255:1\u201311.","journal-title":"Am Heart J"},{"issue":"9","key":"2153_CR13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45269.eCollection2023Sep.PMID:37846270.PMCID:PMC10576845","volume":"15","author":"V Halder","year":"2023","unstructured":"Halder V, Mishra A, Ghosh S, Singh H, Barwad P, Thingnam SK, Dutta ARS, Harunal M. Effectiveness and safety of the Ozaki procedure for aortic valve disease in pediatric patients: a systematic review and meta-analysis. Cureus. 2023;15(9): e45269. https:\/\/doi.org\/10.7759\/cureus.45269.eCollection2023Sep.PMID:37846270.PMCID:PMC10576845.","journal-title":"Cureus"},{"issue":"5","key":"2153_CR14","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.jtcvs.2020.01.087","volume":"161","author":"CW Baird","year":"2021","unstructured":"Baird CW, Cooney B, Ch\u00e1vez M, Sleeper LA, Marx GR, Del Nido PJ. Congenital aortic and truncal valve reconstruction using the Ozaki technique: short-term clinical results. J Thorac Cardiovasc Surg. 2021;161(5):1567\u201377. https:\/\/doi.org\/10.1016\/j.jtcvs.2020.01.087. (Epub 2020 Feb 19).","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2153_CR15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S0022-5223(19)33497-X","volume":"47","author":"VO Bj\u00f6rk","year":"1964","unstructured":"Bj\u00f6rk VO, Hultquist G. Teflon and pericardial aortic valve prostheses. J Thorac Cardiovasc Surg. 1964;47:693\u2013701.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2153_CR16","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1097\/00000658-197006010-00015","volume":"171","author":"HT Bahnson","year":"1970","unstructured":"Bahnson HT, Hardesty RL, Baker LD, Brooks DH, Gall DA. Fabrication and evaluation of tissue leaflets for aortic and mitral valve replacement. Ann Surg. 1970;171:939\u201347.","journal-title":"Ann Surg"},{"key":"2153_CR17","unstructured":"Love JW, Calvin JH, Phela RF, et al. Rapid intraoperative fabrication of an autogenous tissue heart valve: a new technique. Proceedings of the Third International Symposium on Biologic and Bioprosthetic Valves 1986; 691\u2013698."},{"key":"2153_CR18","doi-asserted-by":"publisher","first-page":"434","DOI":"10.5761\/atcs.oa.11.01804","volume":"18","author":"H Yamashita","year":"2012","unstructured":"Yamashita H, Ozaki S, Iwasaki K, et al. Tensile strength of human pericardium treated with glutaraldehyde. Ann Thorac Cardiovasc Surg. 2012;18:434\u20137.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2153_CR19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ejcts.2005.04.041","volume":"28","author":"Z Al Halees","year":"2005","unstructured":"Al Halees Z, Al Shahid M, Al Sanci A, et al. Up-to 16 years follow-up of aortic valve reconstruction with pericardium: a stentless, readily available cheap valve? Eur J Cardiothorac Surg. 2005;28:200\u20135.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"6","key":"2153_CR20","doi-asserted-by":"publisher","first-page":"585","DOI":"10.14503\/THIJ-13-3619","volume":"41","author":"MG Song","year":"2014","unstructured":"Song MG, Yang HS, Choi JB, et al. Aortic valve reconstruction with use of pericardial leaflets in adults with bicuspid aortic valve disease: early and midterm outcomes. Tex Heart Inst J. 2014;41(6):585\u201391.","journal-title":"Tex Heart Inst J"},{"key":"2153_CR21","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.athoracsur.2021.04.099","volume":"113","author":"Z Mitrev","year":"2022","unstructured":"Mitrev Z, Risteski P, Todorovska M, et al. Aortic valve neocuspidization using xenologous pericardium versus bioprosthetic valve replacement. Ann Thorac Surg. 2022;113:1192\u20139.","journal-title":"Ann Thorac Surg"},{"key":"2153_CR22","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1093\/ejcts\/ezaa472","volume":"60","author":"U Benedetto","year":"2021","unstructured":"Benedetto U, Sinha S, Dimagli A, et al. Aortic valve neocuspidization with autologous pericardium in adult patients. Eur J Cardiothorac Surg. 2021;60:34\u201346.","journal-title":"Eur J Cardiothorac Surg"},{"key":"2153_CR23","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/S0003-4975(01)03588-3","volume":"73","author":"R Gnyaneshwar","year":"2002","unstructured":"Gnyaneshwar R, Kumar RK, Balakrishnan KR. Dynamic analysis of the aortic valve using finite element model. Ann Thorac Surg. 2002;73:1122\u20139.","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"2153_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jcct.2024.03.013","volume":"18","author":"I Mokryk","year":"2024","unstructured":"Mokryk I, Batsak B, Nechai I, Stetsyuk I, Todurov B. A personalized aortic valve replacement using computed tomography-guided aortic valve neocuspidization: Analysis of mid-term results compared to standard Ozaki technique. J Cardiovasc Comput Tomogr. 2024;18(4):345\u201351. https:\/\/doi.org\/10.1016\/j.jcct.2024.03.013. (Epub 2024 Mar 28).","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"2153_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1053\/j.pcsu.2012.01.004","volume":"15","author":"CW Baird","year":"2012","unstructured":"Baird CW, Myers PO, del Nido PJ. Aortic valve reconstruction in young infants and children. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2012;15:9\u201319.","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"issue":"2","key":"2153_CR26","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.jtcvs.2018.10.050","volume":"157","author":"D Kalfa","year":"2019","unstructured":"Kalfa D, LaPar D, Chai P, Bacha E. Aortic valve neocuspidization: a bright future in pediatric aortic valve surgery? J Thorac Cardiovasc Surg. 2019;157(2):728. https:\/\/doi.org\/10.1016\/j.jtcvs.2018.10.050. (PMID: 30669233).","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"2153_CR27","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.athoracsur.2020.04.025","volume":"110","author":"SP Marathe","year":"2020","unstructured":"Marathe SP, Ch\u00e1vez M, Sleeper LA, Marx G, Del Nido PJ, Baird CW. Modified Ozaki procedure including annular enlargement for small aortic annuli in young patients. Ann Thorac Surg. 2020;110(4):1364\u201371. https:\/\/doi.org\/10.1016\/j.athoracsur.2020.04.025. (Epub 2020 May 23 PMID: 32454012).","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"2153_CR28","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1177\/2150135119878108","volume":"10","author":"SC Chivers","year":"2019","unstructured":"Chivers SC, Pavy C, Vaja R, Quarto C, Ghez O, Daubeney PEF. The Ozaki procedure with CardioCel patch for children and young adults with aortic valve disease: preliminary experience - a word of caution. World J Pediatr Congenit Heart Surg. 2019;10(6):724\u201330. https:\/\/doi.org\/10.1177\/2150135119878108. (PMID: 31701826).","journal-title":"World J Pediatr Congenit Heart Surg"},{"issue":"11","key":"2153_CR29","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.21037\/tp-23-289","volume":"12","author":"J Huang","year":"2023","unstructured":"Huang J, Zhang W, Jia B, Chen G, Mi Y, Shi Q, Shan Y, Zhang H. A midterm follow-up study of the application of a confluent aortic valve neocuspidization technique with pericardium in children. Transl Pediatr. 2023;12(11):1981\u201391. https:\/\/doi.org\/10.21037\/tp-23-289. (Epub 2023 Nov 24. PMID: 38130583. PMCID: PMC10730963).","journal-title":"Transl Pediatr"},{"issue":"6","key":"2153_CR30","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1016\/j.jtcvs.2019.09.176","volume":"159","author":"LM Wiggins","year":"2020","unstructured":"Wiggins LM, Mimic B, Issitt R, Ilic S, Bonello B, Marek J, Kostolny M. The utility of aortic valve leaflet reconstruction techniques in children and young adults. J Thorac Cardiovasc Surg. 2020;159(6):2369\u201378. https:\/\/doi.org\/10.1016\/j.jtcvs.2019.09.176. (Epub 2019 Oct 26 PMID: 31864692).","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"2153_CR31","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.cir.51.6.1124","volume":"51","author":"ML Epstein","year":"1975","unstructured":"Epstein ML, Goldberg SJ, Allen HD, Konecke L, Wood J. Great vessel, cardiac chamber, and wall growth patterns in normal children. Circulation. 1975;51(6):1124\u20139. https:\/\/doi.org\/10.1161\/01.cir.51.6.1124. (PMID: 1132102).","journal-title":"Circulation"},{"issue":"9","key":"2153_CR32","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/0002-9149(90)91048-b","volume":"65","author":"HP Gutgesell","year":"1990","unstructured":"Gutgesell HP, Rembold CM. Growth of the human heart relative to body surface area. Am J Cardiol. 1990;65(9):662\u20138. https:\/\/doi.org\/10.1016\/0002-9149(90)91048-b. (PMID: 2309636).","journal-title":"Am J Cardiol"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-025-02153-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-025-02153-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-025-02153-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T15:23:18Z","timestamp":1761232998000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-025-02153-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,3]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["2153"],"URL":"https:\/\/doi.org\/10.1007\/s11748-025-02153-y","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"value":"1863-6705","type":"print"},{"value":"1863-6713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,3]]},"assertion":[{"value":"17 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"There is no ethical problem presented. The Clinical and Research Ethics Committee of the Heart Institute approved the clinical study of this procedure (Approval Protocol No.25\/1 from September 23, 2020).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}