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We aimed to compare survival after lobectomy between non-small cell lung cancer in the S6 and basal segments, focusing specifically on pure-solid tumors, which have higher lymph node metastasis rates and worse prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients with pure-solid, clinical N0 M0,\u2009\u2264\u20095-cm, lower-lobe non-small cell lung cancer who underwent lobectomy with hilar and mediastinal lymphadenectomy between April 2009 and December 2021. Overall survival, recurrence-free survival and clinicopathological characteristics were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We categorized 157 patients into S6 (n\u2009=\u200958) and basal segment (n\u2009=\u200999) groups. The 5-year overall survival (66.4% vs. 68.6%, respectively; p\u2009=\u20090.519; hazard ratio, 1.19; 95% confidence interval, 0.70\u20132.03), and recurrence-free survival (54.8% vs. 65.5%, respectively; p\u2009=\u20090.452; hazard ratio, 1.22; 95% confidence interval, 0.72\u20132.06) rates were comparable between the S6 and basal segment groups. Multivariable Cox regression analyses indicated that tumor location was not associated with overall or recurrence-free survival. The S6 group showed a higher tendency for visceral pleural invasion compared with the basal segment group. Superior mediastinal lymph node metastasis was pathologically confirmed exclusively in the S6 group (two cases).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No significant difference in survival was observed between S6 and basal segment pure-solid non-small cell lung cancer after lobectomy with hilar and mediastinal lymph node dissection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11748-025-02202-6","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:23:46Z","timestamp":1758209026000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic comparison between superior and basal segments in pure-solid non-small cell lung cancer"],"prefix":"10.1007","volume":"74","author":[{"given":"Shinji","family":"Yuhara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gouji","family":"Toyokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Konoeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-8573","authenticated-orcid":false,"given":"Masaaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2202_CR1","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.athoracsur.2017.06.060","volume":"104","author":"Y Handa","year":"2017","unstructured":"Handa Y, Tsutani Y, Tsubokawa N, Misumi K, Hanaki H, Miyata Y, et al. 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