{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:55:07Z","timestamp":1772585707114,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009337","name":"Saitama Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009337","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to report \u201creal-world\u201d mid-term clinical experiences and outcomes after surgical mitral valve replacement with the Epic bioprosthesis in a high-volume Japanese heart center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing surgical mitral valve replacement with the Epic bioprosthesis from 2012 to 2023 were enrolled. Postoperative outcomes, survival, and hemodynamic performance were analyzed. The study endpoints were all-cause mortality, freedom from mitral valve reintervention, and major adverse cardiac events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 122 patients (mean age: 73\u2009\u00b1\u20098\u00a0years, 73 males) successfully underwent surgical mitral valve replacement with the Epic bioprosthesis (25\u00a0mm,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922; 27\u00a0mm,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937; 29\u00a0mm,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926; and 31\u00a0mm,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937). The primary valve etiologies were infective endocarditis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917), stenosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), stenosis and regurgitation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913), regurgitation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200973), and thrombosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). The median follow-up period was 33 (interquartile range: 20\u201348) months. Overall survival rates at 1, 3, and 5\u00a0years after mitral valve replacement were 86.8%, 82.0%, and 76.9%. The rates of freedom from rehospitalization for heart failure were 96.7% at 1\u00a0year, 95.5% at 3\u00a0years, and 91.2% at 5\u00a0years. The mean pressure gradient was 5 (interquartile range: 4\u20136.4) mmHg at discharge, 5.4 (interquartile range: 4.3\u20136.9) mmHg at 1\u00a0year, and 5.4 (interquartile range: 4\u20137.5) mmHg at late follow-up (Friedman test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.46). During the study period, only one patient required reintervention because of valve deterioration at 31 postoperative months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinical outcomes of mitral valve replacement with the Epic bioprosthesis are satisfactory, with stable hemodynamics and extremely low incidence of structural valve deterioration and reintervention over 5\u00a0years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11748-025-02212-4","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:38:02Z","timestamp":1761626282000},"page":"271-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mid-term outcomes and hemodynamic performances of Abbott Epic mitral bioprosthesis: a single-center study"],"prefix":"10.1007","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-6704","authenticated-orcid":false,"given":"Takayuki","family":"Gyoten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Miyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiyo","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Akatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Gatate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yoshitake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2212_CR1","unstructured":"Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part\u00a01: Clinical Trial Design Principles: A Consensus Document From the Mitral Valve Academic Research Consortium"},{"key":"2212_CR2","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S0022-5223(98)00450-4","volume":"116","author":"AM Gillinov","year":"1998","unstructured":"Gillinov AM, Cosgrove DM, Blackstone EH, Diaz R, Arnold JH, Lytle BW, et al. 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